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. 1973 Aug;26(8):583–591. doi: 10.1136/jcp.26.8.583

The incidence of germinal centres in thymus glands of patients with congenital heart disease

J M Vetters 1,2, R S Barclay 1,2
PMCID: PMC477829  PMID: 4733862

Abstract

The incidence of thymic germinal centres in normal individuals is disputed by various authors. The present study gives the results of a detailed histological assessment of 75 thymic biopsies obtained during operations to correct congenital heart lesions. Serial sectioning showed structures previously of disputed significance to be obliquely sectioned germinal centres. Comparison with the data of Hammar (1926) showed that there was some stress involution of the glands studied. Despite this 40% of the subjects had thymic germinal centres. Germinal centres were not detected in subjects under 4 years of age and there were insufficient subjects over 16 years of age to allow assessment of the frequency in adult thymus glands.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANDERSON R. M. The thymus gland in myasthenia gravis: a clinico-pathological report. Med J Aust. 1956 Jun 2;43(22):919–921. [PubMed] [Google Scholar]
  2. BURNET F. M., MACKAY I. R. HISTOLOGY OF A THYMUS REMOVED SURGICALLY FROM A PATIENT WITH SEVERE UNTREATED SYSTEMIC LUPUS ERYTHEMATOSUS. J Pathol Bacteriol. 1965 Jan;89:263–270. doi: 10.1002/path.1700890127. [DOI] [PubMed] [Google Scholar]
  3. BURNET F. M. The immunological significance of the thymus: an extension of the clonal selection theory of immunity. Australas Ann Med. 1962 May;11:79–91. doi: 10.1111/imj.1962.11.2.79. [DOI] [PubMed] [Google Scholar]
  4. Bhathal P. S., Campbell P. E. Eosinophil leucocytes in the child's thymus. Australas Ann Med. 1965 Aug;14(3):210–213. doi: 10.1111/imj.1965.14.3.210. [DOI] [PubMed] [Google Scholar]
  5. Goldstein G., Mackay I. R. The thymus in systemic lupus erythematosus: a quantitative histopathological analysis and comparison with stress involution. Br Med J. 1967 May 20;2(5550):475–478. doi: 10.1136/bmj.2.5550.475. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Habu S., Kameya T., Tamaoki N. Thymic lymphoid follicles in autoimmune diseases. I. Quantitative studies with special reference to myasthenia gravis. Keio J Med. 1971 May;20(1):45–56. doi: 10.2302/kjm.20.45. [DOI] [PubMed] [Google Scholar]
  7. Henry K. The thymus in rheumatic heart disease. Clin Exp Immunol. 1968 Jul;3(6):509–523. [PMC free article] [PubMed] [Google Scholar]
  8. Middleton G. The incidence of follicular structures in the human thymus at autopsy. Aust J Exp Biol Med Sci. 1967 Apr;45(2):189–199. doi: 10.1038/icb.1967.14. [DOI] [PubMed] [Google Scholar]
  9. Millikin P. D. Anatomy of germinal centers in human lymphoid tissue. Arch Pathol. 1966 Dec;82(6):499–505. [PubMed] [Google Scholar]
  10. Okabe H. Thymic lymph follicles; a histopathological study of 1,356 autopsy cases. Acta Pathol Jpn. 1966 Feb;16(1):109–130. doi: 10.1111/j.1440-1827.1966.tb01943.x. [DOI] [PubMed] [Google Scholar]

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