Skip to main content
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1973 Sep;26(9):649–659. doi: 10.1136/jcp.26.9.649

Multiple myeloma: Development of plasma cell sarcoma during apparently successful chemotherapy

J M Holt 1,2, A H T Robb-Smith 1,2
PMCID: PMC477846  PMID: 4584727

Abstract

Three patients with multiple myeloma who developed a plasma cell sarcoma during apparently successful chemothapy are described. It is postulated that the chemotherapy induced the sarcomatous change.

Full text

PDF
649

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andersen E., Videbaek A. Stem cell leukaemia in myelomatosis. Scand J Haematol. 1970;7(3):201–207. doi: 10.1111/j.1600-0609.1970.tb01888.x. [DOI] [PubMed] [Google Scholar]
  2. Bösken W., Noltenius H. Grosszelliges Retikulumzellsarkom als Spätzustand einer endoxanbehandelten Makroglobulinämie Waldenström. Zentralbl Allg Pathol. 1968;111(4):407–413. [PubMed] [Google Scholar]
  3. CARSON C. P., ACKERMAN L. V., MALTBY J. D. Plasma cell myeloma; a clinical, pathologic and roentgenologic review of 90 cases. Am J Clin Pathol. 1955 Aug;25(8):849–888. doi: 10.1093/ajcp/25.8.849. [DOI] [PubMed] [Google Scholar]
  4. CHIARI H. UBER EIGENTUEMLICHE VERLAUFSFORMEN VON HAEMOBLASTOSEN. Beitr Pathol Anat. 1964 Jun;130:51–68. [PubMed] [Google Scholar]
  5. CHURG J., GORDON A. J. Multiple myeloma; lesions of the extra-osseous hematopoietic system. Am J Clin Pathol. 1950 Oct;20(10):934–945. doi: 10.1093/ajcp/20.10.934. [DOI] [PubMed] [Google Scholar]
  6. Craft I. L. The late appearance of extramedullary lesions in myelomatosis. Br J Cancer. 1967 Sep;21(3):501–504. doi: 10.1038/bjc.1967.58. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. DOLIN S., DEWAR J. P. Extramedullary plasmacytoma. Am J Pathol. 1956 Jan-Feb;32(1):83–103. [PMC free article] [PubMed] [Google Scholar]
  8. Doak P. B., Montgomerie J. Z., North J. D., Smith F. Reticulum cell sarcoma after renal homotransplantation and azathioprine and prednisone therapy. Br Med J. 1968 Dec 21;4(5633):746–748. doi: 10.1136/bmj.4.5633.746. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Edwards G. A., Zawadzki Z. A. Extraosseous lesions in plasma cell myeloma. A report of six cases. Am J Med. 1967 Aug;43(2):194–205. doi: 10.1016/0002-9343(67)90164-7. [DOI] [PubMed] [Google Scholar]
  10. HAYES D. W., BENNETT W. A., HECK F. J. Extramedullary lesions in multiple myeloma; review of literature and pathologic studies. AMA Arch Pathol. 1952 Mar;53(3):262–272. [PubMed] [Google Scholar]
  11. Holland J. F. Epidemic acute leukemia. N Engl J Med. 1970 Nov 19;283(21):1165–1166. doi: 10.1056/NEJM197011192832111. [DOI] [PubMed] [Google Scholar]
  12. Holt J. M., Robb-Smith A. H., Callender S. T., Spriggs A. I. Multiple myeloma--development of alternative malignancy following successful chemotherapy. Br J Haematol. 1972 May;22(5):633–633. [PubMed] [Google Scholar]
  13. INNES J., NEWALL J. Myelomatosis. Lancet. 1961 Feb 4;1(7171):239–245. doi: 10.1016/s0140-6736(61)91420-9. [DOI] [PubMed] [Google Scholar]
  14. JAMES T. G. I., TURNER E. A. Soft-tissue involvement in multiple myelomatosis. Br J Surg. 1952 Jan;39(156):361–364. doi: 10.1002/bjs.18003915623. [DOI] [PubMed] [Google Scholar]
  15. Kernen J. A., Meyer B. W. Malignant plasmacytoma of the lung with metastases. J Thorac Cardiovasc Surg. 1966 May;51(5):739–744. [PubMed] [Google Scholar]
  16. Kyle R. A., Pierre R. V., Bayrd E. D. Multiple myeloma and acute myelomonocytic leukemia. N Engl J Med. 1970 Nov 19;283(21):1121–1125. doi: 10.1056/NEJM197011192832101. [DOI] [PubMed] [Google Scholar]
  17. Mundy G. R., Baikie A. G. Myeloma treated with cyclophosphamide and terminating in reticulum cell sarcoma. Med J Aust. 1973 Jun 23;1(25):1240–1241. doi: 10.5694/j.1326-5377.1973.tb111073.x. [DOI] [PubMed] [Google Scholar]
  18. NEWMAN W., DIEFENBACH W. C. L., QUINN M., MEYER L. M. A case of acute plasma-cell leukemia supporting the concept of unity of plasmacellular neoplasia. Cancer. 1952 May;5(3):514–520. doi: 10.1002/1097-0142(195205)5:3<514::aid-cncr2820050311>3.0.co;2-b. [DOI] [PubMed] [Google Scholar]
  19. Nordenson N. G. Myelomatosis. A clinical review of 310 cases. Acta Med Scand Suppl. 1966;445:178–186. [PubMed] [Google Scholar]
  20. Okano H., Azar H. A., Osserman E. F. Plasmacytic reticulum cell sarcoma. Case report with electron microscopic studies. Am J Clin Pathol. 1966 Nov;46(5):546–555. doi: 10.1093/ajcp/46.5.546. [DOI] [PubMed] [Google Scholar]
  21. Osserman E. F., Lawlor D. P. Serum and urinary lysozyme (muramidase) in monocytic and monomyelocytic leukemia. J Exp Med. 1966 Nov 1;124(5):921–952. doi: 10.1084/jem.124.5.921. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Pasmantier M. W., Azar H. A. Extraskeletal spread in multiple plasma cell myeloma. A review of 57 autopsied cases. Cancer. 1969 Jan;23(1):167–174. doi: 10.1002/1097-0142(196901)23:1<167::aid-cncr2820230122>3.0.co;2-0. [DOI] [PubMed] [Google Scholar]
  23. Reinshagen G. Lymphknotenplasmocytom der Axilla bei multiplem Myelom. Beitr Pathol Anat. 1966 Jun;133(4):394–408. [PubMed] [Google Scholar]
  24. River G. L., Schorr W. F. Malignant skin tumors in multiple myeloma. Arch Dermatol. 1966 Apr;93(4):432–438. [PubMed] [Google Scholar]
  25. SANDKUHLER S., ROEMHELD L. Myelome mit plasmozytärem Pleuraerguss. Acta Haematol. 1957 Dec;18(6):403–413. doi: 10.1159/000205353. [DOI] [PubMed] [Google Scholar]
  26. Scamps R. A., O'Neill B. J., Newland R. C. A case of multiple myeloma terminating with acute myelomonocytic leukaemia. Med J Aust. 1971 Nov 27;2(22):1129–1130. doi: 10.5694/j.1326-5377.1971.tb92744.x. [DOI] [PubMed] [Google Scholar]
  27. Terbrüggen A. Neoplastische Retikulose nach zytostatischer Dauerbehandlung von radikal operierten Karzinomen. Verh Dtsch Ges Pathol. 1965;49:241–245. [PubMed] [Google Scholar]
  28. WALDENSTROEM J. MELPHALAN THERAPY IN MYELOMATOSIS. Br Med J. 1964 Apr 4;1(5387):859–865. doi: 10.1136/bmj.1.5387.859. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. WUKETICH S., SIEGMUND G. [Multiple plasmocytoma with transition into giant cell reticulum cell sarcoma]. Wien Klin Wochenschr. 1961 Jul 7;73:473–476. [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES