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. 1993 Nov 15;90(22):10413–10420. doi: 10.1073/pnas.90.22.10413

Behavioral and magnetoencephalographic correlates of plasticity in the adult human brain

V S Ramachandran 1
PMCID: PMC47787  PMID: 8248123

Abstract

Recent behavioral and physiological evidence suggests that even brief sensory deprivation can lead to the rapid emergence of new and functionally effective neural connections in the adult human brain.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barker A. T., Jalinous R., Freeston I. L. Non-invasive magnetic stimulation of human motor cortex. Lancet. 1985 May 11;1(8437):1106–1107. doi: 10.1016/s0140-6736(85)92413-4. [DOI] [PubMed] [Google Scholar]
  2. Baumgartner C., Doppelbauer A., Deecke L., Barth D. S., Zeitlhofer J., Lindinger G., Sutherling W. W. Neuromagnetic investigation of somatotopy of human hand somatosensory cortex. Exp Brain Res. 1991;87(3):641–648. doi: 10.1007/BF00227089. [DOI] [PubMed] [Google Scholar]
  3. CRONHOLM B. Phantom limbs in amputees; a study of changes in the integration of centripetal impulses with special reference to referred sensations. Acta Psychiatr Neurol Scand Suppl. 1951;72:1–310. [PubMed] [Google Scholar]
  4. Calford M. B., Tweedale R. Interhemispheric transfer of plasticity in the cerebral cortex. Science. 1990 Aug 17;249(4970):805–807. doi: 10.1126/science.2389146. [DOI] [PubMed] [Google Scholar]
  5. Calford M. Neurobiology. Curious cortical change. Nature. 1991 Aug 29;352(6338):759–760. doi: 10.1038/352759a0. [DOI] [PubMed] [Google Scholar]
  6. Cohen L. G., Bandinelli S., Findley T. W., Hallett M. Motor reorganization after upper limb amputation in man. A study with focal magnetic stimulation. Brain. 1991 Feb;114(Pt 1B):615–627. doi: 10.1093/brain/114.1.615. [DOI] [PubMed] [Google Scholar]
  7. Gilbert C. D., Wiesel T. N. Receptive field dynamics in adult primary visual cortex. Nature. 1992 Mar 12;356(6365):150–152. doi: 10.1038/356150a0. [DOI] [PubMed] [Google Scholar]
  8. HUBEL D. H., WIESEL T. N. Receptive fields, binocular interaction and functional architecture in the cat's visual cortex. J Physiol. 1962 Jan;160:106–154. doi: 10.1113/jphysiol.1962.sp006837. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Heinen S. J., Skavenski A. A. Recovery of visual responses in foveal V1 neurons following bilateral foveal lesions in adult monkey. Exp Brain Res. 1991;83(3):670–674. doi: 10.1007/BF00229845. [DOI] [PubMed] [Google Scholar]
  10. Jenkins W. M., Merzenich M. M., Recanzone G. Neocortical representational dynamics in adult primates: implications for neuropsychology. Neuropsychologia. 1990;28(6):573–584. doi: 10.1016/0028-3932(90)90035-m. [DOI] [PubMed] [Google Scholar]
  11. Jones E. G., Friedman D. P., Hendry S. H. Thalamic basis of place- and modality-specific columns in monkey somatosensory cortex: a correlative anatomical and physiological study. J Neurophysiol. 1982 Aug;48(2):545–568. doi: 10.1152/jn.1982.48.2.545. [DOI] [PubMed] [Google Scholar]
  12. Kaas J. H., Krubitzer L. A., Chino Y. M., Langston A. L., Polley E. H., Blair N. Reorganization of retinotopic cortical maps in adult mammals after lesions of the retina. Science. 1990 Apr 13;248(4952):229–231. doi: 10.1126/science.2326637. [DOI] [PubMed] [Google Scholar]
  13. Kaas J. H., Merzenich M. M., Killackey H. P. The reorganization of somatosensory cortex following peripheral nerve damage in adult and developing mammals. Annu Rev Neurosci. 1983;6:325–356. doi: 10.1146/annurev.ne.06.030183.001545. [DOI] [PubMed] [Google Scholar]
  14. Kaas J. H. Plasticity of sensory and motor maps in adult mammals. Annu Rev Neurosci. 1991;14:137–167. doi: 10.1146/annurev.ne.14.030191.001033. [DOI] [PubMed] [Google Scholar]
  15. Katz J., Melzack R. Referred sensations in chronic pain patients. Pain. 1987 Jan;28(1):51–59. doi: 10.1016/0304-3959(87)91059-1. [DOI] [PubMed] [Google Scholar]
  16. Kreisman N. R., Zimmerman I. D. Cortical unit responses to temperature stimulation of the skin. Brain Res. 1971 Jan 8;25(1):184–187. doi: 10.1016/0006-8993(71)90578-6. [DOI] [PubMed] [Google Scholar]
  17. LANDGREN S. Thalamic neurones responding to cooling of the cat's tongue. Acta Physiol Scand. 1960 Mar 18;48:255–267. doi: 10.1111/j.1748-1716.1960.tb01860.x. [DOI] [PubMed] [Google Scholar]
  18. MOUNTCASTLE V. B. Modality and topographic properties of single neurons of cat's somatic sensory cortex. J Neurophysiol. 1957 Jul;20(4):408–434. doi: 10.1152/jn.1957.20.4.408. [DOI] [PubMed] [Google Scholar]
  19. Merzenich M. M., Kaas J. H., Wall J., Nelson R. J., Sur M., Felleman D. Topographic reorganization of somatosensory cortical areas 3b and 1 in adult monkeys following restricted deafferentation. Neuroscience. 1983 Jan;8(1):33–55. doi: 10.1016/0306-4522(83)90024-6. [DOI] [PubMed] [Google Scholar]
  20. Merzenich M. M., Nelson R. J., Stryker M. P., Cynader M. S., Schoppmann A., Zook J. M. Somatosensory cortical map changes following digit amputation in adult monkeys. J Comp Neurol. 1984 Apr 20;224(4):591–605. doi: 10.1002/cne.902240408. [DOI] [PubMed] [Google Scholar]
  21. Mogilner A., Grossman J. A., Ribary U., Joliot M., Volkmann J., Rapaport D., Beasley R. W., Llinás R. R. Somatosensory cortical plasticity in adult humans revealed by magnetoencephalography. Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3593–3597. doi: 10.1073/pnas.90.8.3593. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Okada Y. C., Tanenbaum R., Williamson S. J., Kaufman L. Somatotopic organization of the human somatosensory cortex revealed by neuromagnetic measurements. Exp Brain Res. 1984;56(2):197–205. doi: 10.1007/BF00236274. [DOI] [PubMed] [Google Scholar]
  23. Pascual-Leone A., Cohen L. G., Hallett M. Cortical map plasticity in humans. Trends Neurosci. 1992 Jan;15(1):13–14. doi: 10.1016/0166-2236(92)90341-5. [DOI] [PubMed] [Google Scholar]
  24. Pons T. P., Garraghty P. E., Ommaya A. K., Kaas J. H., Taub E., Mishkin M. Massive cortical reorganization after sensory deafferentation in adult macaques. Science. 1991 Jun 28;252(5014):1857–1860. doi: 10.1126/science.1843843. [DOI] [PubMed] [Google Scholar]
  25. Ramachandran V. S. Blind spots. Sci Am. 1992 May;266(5):86–91. doi: 10.1038/scientificamerican0592-86. [DOI] [PubMed] [Google Scholar]
  26. Ramachandran V. S., Gregory R. L., Aiken W. Perceptual fading of visual texture borders. Vision Res. 1993 Mar-Apr;33(5-6):717–721. doi: 10.1016/0042-6989(93)90191-x. [DOI] [PubMed] [Google Scholar]
  27. Ramachandran V. S., Gregory R. L. Perceptual filling in of artificially induced scotomas in human vision. Nature. 1991 Apr 25;350(6320):699–702. doi: 10.1038/350699a0. [DOI] [PubMed] [Google Scholar]
  28. Ramachandran V. S., Rogers-Ramachandran D., Stewart M. Perceptual correlates of massive cortical reorganization. Science. 1992 Nov 13;258(5085):1159–1160. doi: 10.1126/science.1439826. [DOI] [PubMed] [Google Scholar]
  29. Ramachandran V. S., Rogers-Ramachandran D., Stewart M. Perceptual correlates of massive cortical reorganization. Science. 1992 Nov 13;258(5085):1159–1160. doi: 10.1126/science.1439826. [DOI] [PubMed] [Google Scholar]
  30. Ramachandran V. S., Stewart M., Rogers-Ramachandran D. C. Perceptual correlates of massive cortical reorganization. Neuroreport. 1992 Jul;3(7):583–586. doi: 10.1097/00001756-199207000-00009. [DOI] [PubMed] [Google Scholar]
  31. Suk J., Ribary U., Cappell J., Yamamoto T., Llinás R. Anatomical localization revealed by MEG recordings of the human somatosensory system. Electroencephalogr Clin Neurophysiol. 1991 Mar;78(3):185–196. doi: 10.1016/0013-4694(91)90032-y. [DOI] [PubMed] [Google Scholar]
  32. WIESEL T. N., HUBEL D. H. SINGLE-CELL RESPONSES IN STRIATE CORTEX OF KITTENS DEPRIVED OF VISION IN ONE EYE. J Neurophysiol. 1963 Nov;26:1003–1017. doi: 10.1152/jn.1963.26.6.1003. [DOI] [PubMed] [Google Scholar]
  33. Wall J. T. Variable organization in cortical maps of the skin as an indication of the lifelong adaptive capacities of circuits in the mammalian brain. Trends Neurosci. 1988 Dec;11(12):549–557. doi: 10.1016/0166-2236(88)90184-1. [DOI] [PubMed] [Google Scholar]
  34. Wall P. D. The presence of ineffective synapses and the circumstances which unmask them. Philos Trans R Soc Lond B Biol Sci. 1977 Apr 26;278(961):361–372. doi: 10.1098/rstb.1977.0048. [DOI] [PubMed] [Google Scholar]
  35. Yang T. T., Gallen C. C., Schwartz B. J., Bloom F. E. Noninvasive somatosensory homunculus mapping in humans by using a large-array biomagnetometer. Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):3098–3102. doi: 10.1073/pnas.90.7.3098. [DOI] [PMC free article] [PubMed] [Google Scholar]

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