Abstract
An interlaboratory trial of the quantitation of Hb A2 and Hb F has been carried out on two samples of blood by 90 laboratories in the British Isles. The results have been compared with those obtained by four reference laboratories. Overall, the correlation was very poor and indicated that the methods used have to be standardized before interlaboratory values become meaningful. Moreover, in many laboratories the level of Hb A2 in a patient with proven beta thalassaemia was not reported as being increased.
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Selected References
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- BETKE K., MARTI H. R., SCHLICHT I. Estimation of small percentages of foetal haemoglobin. Nature. 1959 Dec 12;184(Suppl 24):1877–1878. doi: 10.1038/1841877a0. [DOI] [PubMed] [Google Scholar]
- Marengo-Rowe A. J. Rapid electrophoresis and quantitation of haemoglobins on cellulose acetate. J Clin Pathol. 1965 Nov;18(6):790–792. doi: 10.1136/jcp.18.6.790. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SINGER K., CHERNOFF A. I., SINGER L. Studies on abnormal hemoglobins. I. Their demonstration in sickle cell anemia and other hematologic disorders by means of alkali denaturation. Blood. 1951 May;6(5):413–428. [PubMed] [Google Scholar]
- Weatherall D. J., Gilles H. M., Clegg J. B., Blankson J. A., Mustafa D., Boi-Doku F. S., Chaudhury D. S. Preliminary surveys for the prevalence of the thalassemia genes in some African populations. Ann Trop Med Parasitol. 1971 Jun;65(2):253–265. doi: 10.1080/00034983.1971.11686752. [DOI] [PubMed] [Google Scholar]