Abstract
A clinico-pathological review of 520 patients with hepatic cirrhosis coming to necropsy at the Western Infirmary, Glasgow over the period 1900-69 is reported. There has been an overall increase in incidence of cirrhosis since the 1940s, and this has been largely due to a rise in female incidence. A similar trend in the period 1940-71 has been confirmed at a national level in data abstracted from the Annual Reports of the Registrar General for Scotland.
The mean age at death has risen for both sexes. Aetiologically, the cirrhosis was alcoholic in 18·5%, posticteric in 10·4%, cryptogenic in 61·9%, and haemochromatosis was diagnosed in 7·5%. Primary malignant tumours of liver supervened in 12·3%. The causes of death and the morphological patterns of the cirrhosis are reviewed.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Creutzfeldt W., Beck K. Cirrhosis of the liver. On the aetiology, pathogenesis, results of treatment and period of survival in an unselected series of 560 patients. Ger Med Mon. 1966 Jul;11(7):259–265. [PubMed] [Google Scholar]
- Lieber C. S., Rubin E. Alcoholic fatty liver in man on a high protein and low fat diet. Am J Med. 1968 Feb;44(2):200–206. doi: 10.1016/0002-9343(68)90151-4. [DOI] [PubMed] [Google Scholar]
- MACDONALD R. A. HEMOCHROMATOSIS AND CIRRHOSIS IN DIFFERENT GEOGRAPHIC AREAS. Am J Med Sci. 1965 Jan;249:36–46. doi: 10.1097/00000441-196501000-00006. [DOI] [PubMed] [Google Scholar]
- MACDONALD R. A., MALLORY G. K. The natural history of postnecrotic cirrhosis; a study of 221 autopsy cases. Am J Med. 1958 Mar;24(3):334–357. doi: 10.1016/0002-9343(58)90321-8. [DOI] [PubMed] [Google Scholar]
- PARKER R. G. The incidence of primary hepatic carcinoma in cirrhosis. Proc R Soc Med. 1957 Mar;50(3):145–147. [PMC free article] [PubMed] [Google Scholar]
- Pettigrew N. M., Goudie R. B., Russell R. I., Chaudhuri A. K. Evidence for a role of hepatitis virus B in chronic alcoholic liver disease. Lancet. 1972 Oct 7;2(7780):724–725. doi: 10.1016/s0140-6736(72)92019-3. [DOI] [PubMed] [Google Scholar]
- Powell L. W., Mortimer R., Harris O. D. Cirrhosis of the liver. A comparative study of the four major aetiological groups. Med J Aust. 1971 May 1;1(18):941–950. [PubMed] [Google Scholar]
- Powell W. J., Jr, Klatskin G. Duration of survival in patients with Laennec's cirrhosis. Influence of alcohol withdrawal, and possible effects of recent changes in general management of the disease. Am J Med. 1968 Mar;44(3):406–420. doi: 10.1016/0002-9343(68)90111-3. [DOI] [PubMed] [Google Scholar]
- RUBIN E., KRUS S., POPPER H. Pathogenesis of postnecrotic cirrhosis in alcoholics. Arch Pathol. 1962 Apr;73:288–299. [PubMed] [Google Scholar]
- Rubin E., Lieber C. S. Alcohol-induced hepatic injury in nonalcoholic volunteers. N Engl J Med. 1968 Apr 18;278(16):869–876. doi: 10.1056/NEJM196804182781602. [DOI] [PubMed] [Google Scholar]
- SCHNEIDERBAUR A. ZUR FRAGE DER HAEUFIGKEIT, DER ZUNAHME UND DER ATIOLOGIE DER LEBERZIRRHOSE. Wien Med Wochenschr. 1964 Oct 17;114:738–747. [PubMed] [Google Scholar]
- Stone W. D., Islam N. R., Paton A. The natural history of cirrhosis. Experience with an unselected group of patients. Q J Med. 1968 Jan;37(145):119–132. [PubMed] [Google Scholar]
- Torf S. F., Sapronov N. S., Cherepanova V. P., Gavrovskaia L. K., Kranova L. I. Prevrashchenie m-kholinolitikov v gangliolitikiputem kvarternizatsii aromaticheskimi radikalami. Farmakol Toksikol. 1972 Sep-Oct;35(5):587–589. [PubMed] [Google Scholar]
- Wadman B., Spencer E. S., Werner I. Liver cirrhosis in three Scandinavian communities. An attempt at a critical evaluation of available epidemiologic data. Acta Med Scand. 1971 Mar;189(3):221–230. [PubMed] [Google Scholar]
- Wilkinson P., Santamaria J. N., Rankin J. G. Epidemiology of alcoholic cirrhosis. Australas Ann Med. 1969 Aug;18(3):222–226. doi: 10.1111/imj.1969.18.3.222. [DOI] [PubMed] [Google Scholar]