Abstract
Bacteriostatic agents are frequently recommended as alternatives to penicillin for prophylaxis of bacterial endocarditis. To test the efficacy of this group of antimicrobials, prophylaxis of experimental streptococcal endocarditis was attempted with tetracycline. The number of streptococci colonizing the aortic valves of rabbits was not affected by inhibitory levels of tetracycline, but multiplication was checked. Streptococcis urvived in vegetations for seven days despite the continuous presence of tetracycline, and multiplied when the drug was withdrawn. It is therefore suggested that bacteriostatic agents may be valueless for prophylaxis of bacterial endocarditis.
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Selected References
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- Durack D. T., Beeson P. B. Experimental bacterial endocarditis. II. Survival of a bacteria in endocardial vegetations. Br J Exp Pathol. 1972 Feb;53(1):50–53. [PMC free article] [PubMed] [Google Scholar]
- Durack D. T., Beeson P. B., Petersdorf R. G. Experimental bacterial endocarditis. 3. Production and progress of the disease in rabbits. Br J Exp Pathol. 1973 Apr;54(2):142–151. [PMC free article] [PubMed] [Google Scholar]
- Durack D. T., Petersdorf R. G. Chemotherapy of experimental streptococcal endocarditis. I. Comparison of commonly recommended prophylactic regimens. J Clin Invest. 1973 Mar;52(3):592–598. doi: 10.1172/JCI107220. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gross L., Fried B. M. The Rôle Played by Rheumatic Fever in the Implantation of Bacterial Endocarditis. Am J Pathol. 1937 Sep;13(5):769–798.9. [PMC free article] [PubMed] [Google Scholar]
- HOOK E. W., KAYE D. Prophylaxis of bacterial endocarditis. J Chronic Dis. 1962 Jun;15:635–646. doi: 10.1016/0021-9681(62)90033-4. [DOI] [PubMed] [Google Scholar]
- Khairat O. An effective antibiotic cover for the prevention of endocarditis following dental and other post-operative bacteraemias. J Clin Pathol. 1966 Nov;19(6):561–566. doi: 10.1136/jcp.19.6.561. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Perlman B. B., Freedman L. R. Experimental endocarditis. II. Staphylococcal infection of the aortic valve following placement of a polyethylene catheter in the left side of the heart. Yale J Biol Med. 1971 Oct;44(2):206–213. [PMC free article] [PubMed] [Google Scholar]
- ROTH O., MONTANO G. M., PICCOLO J. A., CAVALLARO A. L., SHARKEY D. C., CELENTANO R. Chlortetracycline (aureomycin) in prevention of bacteremia following oral surgery; attempt to prevent subacute bacterial endocarditis in patients with heart disease. AMA Arch Intern Med. 1953 Oct;92(4):485–489. doi: 10.1001/archinte.1953.00240220033007. [DOI] [PubMed] [Google Scholar]