Table 3.
Mass, surface area and particle concentration as cellular dose metric, based on administered and deposited doses for all ENMs dispersed in RPMI+10% FBS at a mass concentration of 50μg/mL following 24h exposure. The dose estimates derived from the ISDD model calculations with effective density measurements (Hinderliter et al 2010; Cohen et al 2012) based on delivered ENM mass dose to cells over time. Reproduced in parts with permission from Pal et al. ACS Nano, 2014, 8 (9), pp 9003–9015.
| Nanomaterial Label | Effective density ρe (g/cm3) | Deposition fraction constant α (h−1) | t90 (h) | Administered dose | Deposited dose | |||
|---|---|---|---|---|---|---|---|---|
| Mass (μg) | SA (cm2) | Mass (μg) | SA (cm2) | Particles /cm2 | ||||
| SWCNHs-ox | 1.25 | 0.010 | 227.34 | 10 | 11.54 | 1.88 | 2.17 | 1.97E+08 |
| N110 | 1.04 | 0.010 | 224.11 | 10 | 1.11 | 1.92 | 0.21 | 1.59E+08 |
| Printex-90 | 1.24 | 0.020 | 117.50 | 10 | 2.36 | 3.4 | 0.80 | 7.76E+08 |
| TiO2 P25 | 1.31 | 0.082 | 27.99 | 10 | 2.74 | 9.84 | 2.70 | 3.76E+08 |
| CeO2 | 1.69 | 0.046 | 50.23 | 10 | 0.87 | 7.35 | 0.64 | 6.75E+08 |
| Ni Inco | 1.78 | 0.026 | 88.00 | 10 | 0.91 | 4.46 | 0.41 | 5.18E+08 |
| MnOx PALAS | 1.52 | 0.033 | 68.91 | 10 | 0.58 | 5.73 | 0.33 | 5.94E+08 |
| nAg | 2.30 | 0.050 | 46.37 | 10 | 0.18 | 7.6 | 0.14 | 1.38E+09 |
SA: Surface area
Note: Surface area and particle number concentration dose metrics are based on ISDD model calculations. RID functions can be calculated by inserting appropriate alpha parameter, hydrodynamic diameter and effective density reported in Table 2 into equations 5, 6 or 7 for delivered mass, surface area, and particle number after a given exposure duration.