Table 3. Univariate analysis of prognostic factors in patients with NK/T-cell lymphoma.
| Variable | OS | PFS | ||
|---|---|---|---|---|
| HR (95% CI)a | P value | HR (95% CI)a | P value | |
| Gender (female vs. male) | 0.70 (0.47–1.05) | 0.081 | 0.80 (0.56–1.14) | 0.215 |
| Age (>60 vs. ≤60 years) | 2.27 (1.51–3.40) | 0.000 | 1.61 (1.07–2.41) | 0.022 |
| BMI | 0.97 (0.92–1.02) | 0.234 | 0.99 (0.95–1.04) | 0.744 |
| ECOG score (≥2 vs. 0–1) | 4.04 (2.57–5.93) | 0.000 | 4.48 (3.14–6.39) | 0.000 |
| Primary site (EUAT vs. UAT) | 1.75 (1.09–2.83) | 0.022 | 2.36 (1.54–3.60) | 0.000 |
| Stage (III–IV vs. I–II) | 3.63 (2.50–5.27) | 0.000 | 3.88 (2.75–5.48) | 0.000 |
| B symptoms (yes vs. no) | 1.65 (1.16–2.36) | 0.006 | 1.77 (1.27–2.45) | 0.001 |
| LDH (elevated vs. normal) | 2.58 (1.81–3.67) | 0.000 | 2.30 (1.67–3.19) | 0.000 |
| Involvement of regional lymph nodes | 2.10 (1.48–2.98) | 0.000 | 2.15 (1.57–2.97) | 0.000 |
| Extranodal sites (≥2 vs. 0–1) | 4.38 (2.94–6.53) | 0.000 | 5.05 (3.46–7.38) | 0.000 |
| AGR per unit increase | 0.32 (0.17–0.61) | 0.000 | 0.38 (0.22–0.68) | 0.001 |
| AGR (<1.3 vs. ≥1.3) | 2.09 (1.47–2.97) | 0.000 | 2.09 (1.51–2.88) | 0.000 |
| Total protein | 0.91 (0.96–0.98) | 0.000 | 0.97 (0.96–0.99) | 0.000 |
| Serum albumin | 0.90 (0.87–0.93) | 0.000 | 0.90 (0.87–0.93) | 0.000 |
| WBC count | 0.92 (0.85–0.99) | 0.026 | 0.94 (0.87–1.00) | 0.062 |
| Neutrophil count | 0.95 (0.88–1.04) | 0.269 | 0.98 (0.91–1.05) | 0.511 |
| Lymphocyte count | 0.50 (0.37–0.68) | 0.000 | 0.52 (0.39–0.69) | 0.000 |
| CRP (n = 246) | 1.01 (1.00 –1.02) | 0.008 | 1.01 (1.00–1.02) | 0.003 |
| ESR (n = 117) | 1.00 (0.99–1.01) | 0.647 | 1.00 (0.99–1.01) | 0.737 |
| Serum creatinine | 1.00 (0.99–1.01) | 0.552 | 1.00 (0.99–1.01) | 0.979 |
| IPI score | 1.74 (1.55–1.95) | 0.000 | 1.70 (1.53–1.89) | 0.000 |
| NKPI score | 1.65 (1.43–1.90) | 0.000 | 1.65 (1.45–1.88) | 0.000 |
| Treatment (chemo alone vs. RT ± chemo) | 4.55 (3.19–6.49) | 0.000 | 4.31 (3.12–5.95) | 0.000 |
| Chemotherapeutic regimens (anthracycline-based vs. ASP-containing) | 1.92 (1.26–2.93) | 0.002 | 2.00 (1.37–2.92) | 0.000 |
Notes.
a
The hazard ratio gives the increase in risk for each unit increase for the continuous variables and gives the increased risk relative to the reference category for the categorical variables.
- AGR
- albumin to globulin ration
- ASP
- asparaginase
- BMI
- body mass index
- CI
- confidence interval
- CRP
- C-reactive protein
- ECOG
- Eastern Cooperative Oncology Group
- ESR
- erythrocyte sedimentation rate
- EUAT
- extra-upper aerodigestive tract
- HR
- hazard ratio
- IPI
- International Prognostic Index
- LDH
- lactate dehydrogenase
- NKPI
- natural killer/T-cell lymphoma prognostic index
- OS
- overall survival
- PFS
- progression free survival
- RT
- radiotherapy
- UAT
- upper aerodigestive tract
- WBC
- white blood cell