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. 1972 May;26(2):67–88. doi: 10.1136/jech.26.2.67

Hypothesis: anencephaly and spina bifida are usually preventable by avoidance of a specific but unidentified substance present in certain potato tubers.

J H Renwick
PMCID: PMC478703  PMID: 4558508

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Selected References

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  1. ALTER M. Anencephalus, hydrocephalus, and spina bifida. Epidemiology, with special reference to a survey in Charleston, S.C. Arch Neurol. 1962 Nov;7:411–422. doi: 10.1001/archneur.1962.04210050047005. [DOI] [PubMed] [Google Scholar]
  2. ANDERSON W. J., BAIRD D., THOMSON A. M. Epidemiology of stillbirths and infant deaths due to congenital malformation. Lancet. 1958 Jun 21;1(7034):1304–1306. doi: 10.1016/s0140-6736(58)92062-2. [DOI] [PubMed] [Google Scholar]
  3. Abou-Daoud K. T. Congenital malformations observed in 12146 births at the American University Hospital in Beirut. J Med Liban. 1966 May-Jun;19(3):113–121. [PubMed] [Google Scholar]
  4. Austin D. J., Clarke D. D. Production of coumarins by Phytophthora infestans. Nature. 1966 Jun 11;210(5041):1165–1166. doi: 10.1038/2101165a0. [DOI] [PubMed] [Google Scholar]
  5. Barrow M. V., Steffek A. J., King C. T. Thalidomide syndrome in rhesus monkeys (Macaca mulatta). Folia Primatol (Basel) 1969;10(3):195–203. doi: 10.1159/000155199. [DOI] [PubMed] [Google Scholar]
  6. Beolchini P. E., Bailo U. Sull'esistenza di variazioni stagionali della frequenza dell'anencefalia. Minerva Ginecol. 1965 Sep 30;17(18):928–934. [PubMed] [Google Scholar]
  7. COFFEY V. P., JESSOP W. J. A study of 137 cases of anencephaly. Br J Prev Soc Med. 1957 Oct;11(4):174–180. doi: 10.1136/jech.11.4.174. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Canzler E., Funk G., Schlegel L. Die Missbildungshäufigkeit an der Universitäts-Frauenklinik Leipzig in den Jahren 1941 bis 1965. I. Missbildungshäufigkeit unter besonderer Berückwichtigung der Gestosen. Zentralbl Gynakol. 1969 Jun 28;91(26):833–847. [PubMed] [Google Scholar]
  9. Carter C. O., Roberts J. A. The risk of recurrence after two children with central-nervous-system malformations. Lancet. 1967 Feb 11;1(7485):306–308. doi: 10.1016/s0140-6736(67)91240-8. [DOI] [PubMed] [Google Scholar]
  10. Cassady G. Anencephaly. A 6 year study of 367 cases. Am J Obstet Gynecol. 1969 Apr 15;103(8):1154–1159. [PubMed] [Google Scholar]
  11. Cruz-Coke R. Birth control and sex ratio. Lancet. 1970 Aug 22;2(7669):426–426. doi: 10.1016/s0140-6736(70)90048-6. [DOI] [PubMed] [Google Scholar]
  12. Czeizel A., Révész C. Major malformations of the central nervous system in Hungary. Br J Prev Soc Med. 1970 Nov;24(4):205–222. doi: 10.1136/jech.24.4.205. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Damyanov I., Dutz W. Anencephaly in Shiraz, Iran. Lancet. 1971 Jan 9;1(7689):82–82. doi: 10.1016/s0140-6736(71)90808-7. [DOI] [PubMed] [Google Scholar]
  14. EDWARDS J. H. Congenital malformations of the central nervous system in Scotland. Br J Prev Soc Med. 1958 Jul;12(3):115–130. doi: 10.1136/jech.12.3.115. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. ERHARDT C. L., NELSON F. G. REPORTED CONGENITAL MALFORMATIONS IN NEW YORK CITY, 1958-1959. Am J Public Health Nations Health. 1964 Sep;54:1489–1506. doi: 10.2105/ajph.54.9.1489. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Elwood J. H. Anencephalus in Belfast. Incidence and secular and seasonal variations, 1950-66. Br J Prev Soc Med. 1970 May;24(2):78–88. doi: 10.1136/jech.24.2.78. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Elwood J. H., MacKenzie G. Comparisons of secular and seasonal variations in the incidence of anencephalus in Belfast and four Scottish cities, 1956-66. Br J Prev Soc Med. 1971 Feb;25(1):17–25. doi: 10.1136/jech.25.1.17. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. FOGEL B. J., NITOWSKY H. M., GRUENWALD P. DISCORDANT ABNORMALITIES IN MONOZYGOTIC TWINS. J Pediatr. 1965 Jan;66:64–72. doi: 10.1016/s0022-3476(65)80338-9. [DOI] [PubMed] [Google Scholar]
  19. FREZAL J., KELLEY J., GUILLEMOT M. L., LAMY M. ANENECEPHALY IN FRANCE. Am J Hum Genet. 1964 Sep;16:336–350. [PMC free article] [PubMed] [Google Scholar]
  20. Fedrick J. Anencephalus: variation with maternal age, parity, social class and region in England, Scotland and Wales. Ann Hum Genet. 1970 Jul;34(1):31–38. doi: 10.1111/j.1469-1809.1970.tb00217.x. [DOI] [PubMed] [Google Scholar]
  21. Fielding D. W., Smithells R. W. Anencephalus and water hardness in south-west Lancashire. Br J Prev Soc Med. 1971 Nov;25(4):217–219. doi: 10.1136/jech.25.4.217. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. GITTELSOHN A. M., MILHAM S. Declining incidence of central nervous system anomalies in New York State. Br J Prev Soc Med. 1962 Jul;16:153–158. doi: 10.1136/jech.16.3.153. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. GREEN C. R. THE FREQUENCY OF MALDEVELOPMENT IN MAN: THE NEED FOR IMPROVED STATISTICS. Am J Obstet Gynecol. 1964 Dec 1;90:SUPPL–SUPPL1013. doi: 10.1016/0002-9378(64)90831-2. [DOI] [PubMed] [Google Scholar]
  24. GUTHKELCH A. N. Studies in spina bifida cystica. III. Seasonal variation in the frequency of spina bifida births. Br J Prev Soc Med. 1962 Jul;16:159–162. doi: 10.1136/jech.16.3.159. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. HEWITT D. Geographical variations in the mortality attributed to spina bifida and other congenital malformations. Br J Prev Soc Med. 1963 Jan;17:13–22. doi: 10.1136/jech.17.1.13. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. HORNE H. W., Jr Anencephaly in four consecutive pregnancies; report of a case. Fertil Steril. 1958 Jan-Feb;9(1):67–68. doi: 10.1016/s0015-0282(16)32948-x. [DOI] [PubMed] [Google Scholar]
  27. Halevi H. S. Congenital malformations in Israel. Br J Prev Soc Med. 1967 Apr;21(2):66–77. doi: 10.1136/jech.21.2.66. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Hay S. Sex differences in the incidence of certain congenital malformations: a review of the literature and some new data. Teratology. 1971 Aug;4(3):277–286. doi: 10.1002/tera.1420040303. [DOI] [PubMed] [Google Scholar]
  29. Horowitz I., McDonald A. D. Anencephaly and spina bifida in the Province of Quebec. Can Med Assoc J. 1969 Apr 26;100(16):748–755. [PMC free article] [PubMed] [Google Scholar]
  30. Howie R. N., Phillips L. I. Congenital malformations in the newborn: a survey at the National Women's Hospital, 1964-67. N Z Med J. 1970 Feb;71(453):65–71. [PubMed] [Google Scholar]
  31. INGALLS T. H., KLINGBERG M. A. CONGENITAL MALFORMATIONS. CLINICAL AND COMMUNITY CONSIDERATIONS. Am J Med Sci. 1965 Mar;249:316–344. doi: 10.1097/00000441-196503000-00011. [DOI] [PubMed] [Google Scholar]
  32. Jones W. R. Anencephalus: a 23-year survey in a Sydney hospital. Med J Aust. 1967 Jan 21;1(3):104–106. doi: 10.5694/j.1326-5377.1967.tb21053.x. [DOI] [PubMed] [Google Scholar]
  33. KLINE B. E., VON ELBE H., DAHLE N. A., KUPCHAN S. M. Toxic effects of potato sprouts and of solanine fed to pregnant rats. Proc Soc Exp Biol Med. 1961 Aug-Sep;107:807–809. doi: 10.3181/00379727-107-26762. [DOI] [PubMed] [Google Scholar]
  34. Knox E. G. Spina bifida in Birmingham. Dev Med Child Neurol. 1967;(Suppl):14–22. doi: 10.1111/j.1469-8749.1967.tb02378.x. [DOI] [PubMed] [Google Scholar]
  35. Kolah P. J., Master P. A., Sanghvi L. D. Congenital malformations and perinatal mortality in Bombay. Am J Obstet Gynecol. 1967 Feb 1;97(3):400–406. doi: 10.1016/0002-9378(67)90505-4. [DOI] [PubMed] [Google Scholar]
  36. Kuypers H. M., Huisjes H. J. Anencefalie. Ned Tijdschr Geneeskd. 1971 Jun 19;115(25):1075–1080. [PubMed] [Google Scholar]
  37. Källén B., Winberg J. A Swedish register of congenital malformations. Experience with continuous registration during 2 years with special reference to multiple malformations. Pediatrics. 1968 Apr;41(4):765–776. [PubMed] [Google Scholar]
  38. LORBER J. THE FAMILY HISTORY OF SPINA BIFIDA CYSTICA. Pediatrics. 1965 Apr;35:589–595. [PubMed] [Google Scholar]
  39. Laurence K. M., Carter C. O., David P. A. Major central nervous system malformations in South Wales. I. Incidence, local variations and geographical factors. Br J Prev Soc Med. 1968 Jul;22(3):146–160. doi: 10.1136/jech.22.3.146. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. Leck I. Changes in the incidence of neural-tube defects. Lancet. 1966 Oct 8;2(7467):791–793. doi: 10.1016/s0140-6736(66)90383-7. [DOI] [PubMed] [Google Scholar]
  41. Lowe C. R., Roberts C. J., Lloyd S. Malformations of central nervous system and softness of local water supplies. Br Med J. 1971 May 15;2(5758):357–361. doi: 10.1136/bmj.2.5758.357. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. MACMAHON B., PUGH T. F., INGALLS T. H. Anencephalus, spina bifida, and hydrocephalus incidence related to sex, race, and season of birth, and incidence in siblings. Br J Prev Soc Med. 1953 Oct;7(4):211–219. doi: 10.1136/jech.7.4.211. [DOI] [PMC free article] [PubMed] [Google Scholar]
  43. MUFARRIJ I. K., KILEJIAN V. O. ANENCEPHALY. AN ANALYSIS OF ANENCEPHALIC BIRTHS AND A REPORT OF A CASE OF REPEATED ANENCEPHALY. Obstet Gynecol. 1963 Nov;22:657–661. [PubMed] [Google Scholar]
  44. MacMAHON B., RECORD R. G., McKEOWN T. Secular changes in the incidence of malformations of the central nervous system. Br J Soc Med. 1951 Oct;5(4):254–258. doi: 10.1136/jech.5.4.254. [DOI] [PMC free article] [PubMed] [Google Scholar]
  45. McDONALD A. D. Maternal health and congenital defect; a prospective investigation. N Engl J Med. 1958 Apr 17;258(16):767–773. doi: 10.1056/NEJM195804172581601. [DOI] [PubMed] [Google Scholar]
  46. McKEOWN T., RECORD R. G. Seasonal incidence of congenital malformations of the central nervous system. Lancet. 1951 Jan 27;1(6648):192–196. doi: 10.1016/s0140-6736(51)93354-5. [DOI] [PubMed] [Google Scholar]
  47. Mittwoch U., Delhanty J. D., Beck F. Growth of differentiating testes and ovaries. Nature. 1969 Dec 27;224(5226):1323–1325. doi: 10.1038/2241323a0. [DOI] [PubMed] [Google Scholar]
  48. NEEL J. V. A study of major congenital defects in Japanese infants. Am J Hum Genet. 1958 Dec;10(4):398–445. [PMC free article] [PubMed] [Google Scholar]
  49. Naggan L., MacMahon B. Ethnic differences in the prevalence of anencephaly and sina bifida in Boston, Massachusetts. N Engl J Med. 1967 Nov 23;277(21):1119–1123. doi: 10.1056/NEJM196711232772104. [DOI] [PubMed] [Google Scholar]
  50. Naggan L. The recent decline in prevalence of anencephaly and spina bifida. Am J Epidemiol. 1969 Feb;89(2):154–160. doi: 10.1093/oxfordjournals.aje.a120924. [DOI] [PubMed] [Google Scholar]
  51. Nishie K., Gumbmann M. R., Keyl A. C. Pharmacology of solanine. Toxicol Appl Pharmacol. 1971 May;19(1):81–92. doi: 10.1016/0041-008x(71)90192-x. [DOI] [PubMed] [Google Scholar]
  52. PITT D. B., SAMSON P. E. Congenital malformations and maternal diet. Australas Ann Med. 1961 Nov;10:268–274. doi: 10.1111/imj.1961.10.4.268. [DOI] [PubMed] [Google Scholar]
  53. PLEYDELL M. J. Anencephaly and other congenital abnormalities. An epidemiological study in Northamptonshire. Br Med J. 1960 Jan 30;1(5169):309–315. doi: 10.1136/bmj.1.5169.309. [DOI] [PMC free article] [PubMed] [Google Scholar]
  54. Price R. A., Gilles F. H. Telencephalic remnants in simian and human anencephaly. Arch Pathol. 1971 Jun;91(6):529–536. [PubMed] [Google Scholar]
  55. RECORD R. G. Anencephalus in Scotland. Br J Prev Soc Med. 1961 Jul;15:93–105. doi: 10.1136/jech.15.3.93. [DOI] [PMC free article] [PubMed] [Google Scholar]
  56. Richards I. D. Congenital malformations and environmental influences in pregnancy. Br J Prev Soc Med. 1969 Nov;23(4):218–225. doi: 10.1136/jech.23.4.218. [DOI] [PMC free article] [PubMed] [Google Scholar]
  57. Rogers S. C., Morris M. Infant mortality from spina bifida, congenitalhydrocephalus, monstrosity, and congenital dseases of the cardiovascular system in England and Wales. Ann Hum Genet. 1971 Feb;34(3):295–305. doi: 10.1111/j.1469-1809.1971.tb00242.x. [DOI] [PubMed] [Google Scholar]
  58. SEARLE A. G. The incidence of anencephaly in a polytypic population. Ann Hum Genet. 1959 Jul;23:279–288. doi: 10.1111/j.1469-1809.1959.tb01471.x. [DOI] [PubMed] [Google Scholar]
  59. SLATER B. C., WATSON G. I., MCDONALD J. C. SEASONAL VARIATION IN CONGENITAL ABNORMALITIES. PRELIMINARY REPORT OF A SURVEY CONDUCTED BY THE RESEARCH COMMITTEE OF COUNCIL OF THE COLLEGE OF GENERAL PRACTITIONERS. Br J Prev Soc Med. 1964 Jan;18:1–7. doi: 10.1136/jech.18.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  60. SMITHELLS R. W., CHINN E. R., FRANKLIN D. ANENCEPHALY IN LIVERPOOL. Dev Med Child Neurol. 1964 Jun;6:231–240. doi: 10.1111/j.1469-8749.1964.tb10782.x. [DOI] [PubMed] [Google Scholar]
  61. SMITHELLS R. W., CHINN E. R. SPINA BIFIDA IN LIVERPOOL. Dev Med Child Neurol. 1965 Jun;7:258–268. [PubMed] [Google Scholar]
  62. STEVENSON A. C., WARNOCK H. A. Observations on the results of pregnancies in women resident in Belfast. I. Data relating to all pregnancies ending in 1957. Ann Hum Genet. 1959 Dec;23:382–394. doi: 10.1111/j.1469-1809.1959.tb01481.x. [DOI] [PubMed] [Google Scholar]
  63. Spellman M. P. Anencephaly--a five year survey in Cork. J Ir Med Assoc. 1969 Sep;62(387):316–320. [PubMed] [Google Scholar]
  64. Stocks P. Incidence of congenital malformations in the regions of England and Wales. Br J Prev Soc Med. 1970 May;24(2):67–77. doi: 10.1136/jech.24.2.67. [DOI] [PMC free article] [PubMed] [Google Scholar]
  65. Tünte W. Zur Häufigkeit angeborener Missbildungen des Zentralnervensystems und des Verdauungstraktes in den Jahren 1950-1961. Humangenetik. 1968;6(1):29–33. doi: 10.1007/BF00287151. [DOI] [PubMed] [Google Scholar]
  66. WEI P. Y., CHEN Y. P. CONGENITAL MALFORMATIONS, ESPECIALLY ANENCEPHALUS, IN TAIWAN. Am J Obstet Gynecol. 1965 Mar 15;91:870–876. doi: 10.1016/0002-9378(65)90467-9. [DOI] [PubMed] [Google Scholar]
  67. WILSON G. S. A small outbreak of solanine poisoning. Mon Bull Minist Health Public Health Lab Serv. 1959 Dec;18:207–210. [PubMed] [Google Scholar]
  68. Westlung K. Mortality from congenital malformations of the central nervous system in Norway, 1951-65. Life insurance companies' institute for medical statistics at the Oslo city hospitals, report no. 12. Br J Prev Soc Med. 1969 Feb;23(1):28–33. doi: 10.1136/jech.23.1.28. [DOI] [PMC free article] [PubMed] [Google Scholar]
  69. Yen S., MacMahon B. Genetics of anencephaly and spina bifida? Lancet. 1968 Sep 14;2(7568):623–626. doi: 10.1016/s0140-6736(68)90709-5. [DOI] [PubMed] [Google Scholar]
  70. le Vann L. J. Congenital Abnormalities in Children Born in Alberta During 1961: A Survey and a Hypothesis. Can Med Assoc J. 1963 Jul 20;89(3):120–126. [PMC free article] [PubMed] [Google Scholar]

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