. Author manuscript; available in PMC: 2016 May 18.

Published in final edited form as: Nature. 2015 Oct 28;527(7578):329–335. doi: 10.1038/nature15756

Extended Data Table 1.

Integrin expression in human exosomes in multiple organotropic tumour models

Sites of metastasis	None		Bone	Brain				Lung									Liver
Cell type	Lung Fibroblast	Mammary Epithelial	Breast Cancer			Melanoma		Breast Cancer			Osteosarcoma	Rhabdomyosarcoma		Wilms’ Tumor		Melanoma	Uveal melanoma	Colorectal Cancer			Pancreatic Cancer				Gastric Cancer
Cell line	WI-38	MCF10A	1833	831	231BR	131/4-5B2	SB1B	4173	4175	4180	143B	RD	CT10	CCG 9911	CLS1	131/8-2L	Primary culture	HCT116	HT29	SW620	BXPC-3	HPAF-II	MiaPaca-2	PANC-1	SNU1	SNU16
ITGα₁							+	+		+							+			+	+
ITGα₂			+	+	+	+	+	+	+	+	+			+		+	+	+	+	+	+	+	+
ITGα_2b							+														+
ITGα₃		+	+	+	+			+	+	+	+						+	+	+		+	+	+
ITGα₄						+					+	+		+	+	+	+
ITGα₅							+	+	+	+		+	+		+								+	+	+
ITGα₆				+	+		+	+	+	+	+	+	+	+	+	+	+			+	+	+	+	+	+	+
ITGα₁₁										+
ITGα_v				+		+	+	+	+	+	+	+	+		+	+	+	+		+	+	+	+	+	+
ITGβ₁		+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+
ITGβ₃				+	+	+	+	+		+	+	+	+	+	+	+	+	+		+	+	+	+
ITGβ₄							+	+	+	+								+	+	+	+	+	+			+
ITGβ₅	+			+			+	+	+	+		+	+		+		+	+	+	+	+	+	+	+	+	+
ITGβ₆																					+	+	+

Proteomic analysis of integrins in exosomes. ‘+’ indicates positive for integrin expression by qualitative mass spectrometry.