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. Author manuscript; available in PMC: 2016 Mar 13.
Published in final edited form as: Biochemistry. 2015 May 6;54(19):2943–2956. doi: 10.1021/acs.biochem.5b00292

Figure 2.

Figure 2

The A546T FAS1-4 fibril core is stable over prolonged periods of time. The level of resistance towards hydrogen deuterium exchange in fibrillated A546T FAS1-4 was tested by prolonged incubation in deuterated buffer. The fibrils were allowed to exchange hydrogens for 72 h, followed by quenching and proteolysis with pepsin. Each bar represents the deuterium uptake of a peptic peptide relative to a fully deuterated monomer. The data represent the average deuterium uptake of three replicates. Error bars denote standard deviations.