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Schematic representation of identified core regions in A546T FAS1-4. Linear representation of the A546T FAS1-4 domain, including the N-terminally added residues AG and the naturally occurring C-terminal. Tryptic cleavage sites are represented by lines, and the mutational site of A546T is represented by an asterisk. The fibril core regions identified by HDX-MS and proteolysis are depicted along with the two fibrillating tryptic peptides from A546T FAS1-4, F515-R533 and Y571-R588.
