Abstract
In a study of 100 women with breast cancer and 200 unaffected women the epidemiological characteristic of breast cancer most commonly described--namely, an excess of nonparous women among cases when compared with controls, was not observed. It is suggested that two factors, a dearth of first births born to mothers under 20 years of age and an unusually high proportion of first births when aged 30 years or more, are responsible for this finding. No association was found between breast cancer and socioeconomic status, marital status, age at marriage, age at first pregnancy, parity, or age at menarche. Significant associations with breast cancer included age at natural menopause, hysterectomy, and breast trauma. These findings are discussed.
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Selected References
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- Feinleib M. Breast cancer and artificial menopause: a cohort study. J Natl Cancer Inst. 1968 Aug;41(2):315–329. [PubMed] [Google Scholar]
- Kaplan S. D., Acheson R. M. A single etiological hypothesis for breast cancer? J Chronic Dis. 1966 Nov-Dec;19(11):1221–1230. doi: 10.1016/0021-9681(66)90020-8. [DOI] [PubMed] [Google Scholar]
- LILIENFELD A. M. The relationship of cancer of the female breast to artificial menopause and martial status. Cancer. 1956 Sep-Oct;9(5):927–934. doi: 10.1002/1097-0142(195609/10)9:5<927::aid-cncr2820090510>3.0.co;2-3. [DOI] [PubMed] [Google Scholar]
- Lowe C. R., MacMahon B. Breast cancer and reproductive history of women in South Wales. Lancet. 1970 Jan 24;1(7639):153–156. doi: 10.1016/s0140-6736(70)90401-0. [DOI] [PubMed] [Google Scholar]
- MACMAHON B., FEINLEIB M. Breast cancer in relation to nursing and menopausal history. J Natl Cancer Inst. 1960 Mar;24:733–753. doi: 10.1093/jnci/24.3.733. [DOI] [PubMed] [Google Scholar]
- MacMahon B., Cole P., Lin T. M., Lowe C. R., Mirra A. P., Ravnihar B., Salber E. J., Valaoras V. G., Yuasa S. Age at first birth and breast cancer risk. Bull World Health Organ. 1970;43(2):209–221. [PMC free article] [PubMed] [Google Scholar]
- Ravnihar B., MacMahon B., Lindtner J. Epidemiologic features of breast cancer in Slovenia, 1965-1967. Eur J Cancer. 1971 Aug;7(4):295–306. doi: 10.1016/0014-2964(71)90072-7. [DOI] [PubMed] [Google Scholar]
- STOCKS P. Social status in relation to carcinoma of the breast. Schweiz Z Pathol Bakteriol. 1955;18(4):706–717. doi: 10.1159/000160825. [DOI] [PubMed] [Google Scholar]
- Salber E. J., Trichopulos D., MacMahon B. Lactation and reproductive histories of breast cancer patients in Boston, 1965-66. J Natl Cancer Inst. 1969 Nov;43(5):1013–1024. [PubMed] [Google Scholar]
- Trichopoulos D., MacMahon B., Cole P. Menopause and breast cancer risk. J Natl Cancer Inst. 1972 Mar;48(3):605–613. [PubMed] [Google Scholar]
- Valaoras V. G., MacMahon B., Trichopoulos D., Polychronopoulou A. Lactation and reproductive histories of breast cancer patients in greater Athens, 1965-67. Int J Cancer. 1969 May 15;4(3):350–363. doi: 10.1002/ijc.2910040312. [DOI] [PubMed] [Google Scholar]
- WYNDER E. L., BROSS I. J., HIRAYAMA T. A study of the epidemiology of cancer of the breast. Cancer. 1960 May-Jun;13:559–601. doi: 10.1002/1097-0142(196005/06)13:3<559::aid-cncr2820130322>3.0.co;2-0. [DOI] [PubMed] [Google Scholar]
- Yuasa S., MacMahon B. Lactation and reproductive histories of breast cancer patients in Tokyo, Japan. Bull World Health Organ. 1970;42(2):195–204. [PMC free article] [PubMed] [Google Scholar]