Figure 1.

Concentration values for individuals for Orexin A (hypocretin-1) are shown for those values out (closed circles) and in (open circles) of the episode; patients values are connected by a line. On the right are values in different patients measured either in or out of the hypersomia episode. Individual values are shown as circles, and group values presented as mean ± standard deviation by a dash and whiskers. The literature lower limit of normal for CSF orexin is 110 pg/mL. Differences are significant (P < 0.001 P for: values in and out of episode in the same patient (A vs B, n = 18), paired t-test, and between values for groups of patients in (C, n = 7) or out of episode (D, n = 8), non-paired t-test.