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Journal of Obesity logoLink to Journal of Obesity
. 2016 Mar 2;2016:2361290. doi: 10.1155/2016/2361290

Corrigendum to “Genetic and Diet-Induced Obesity Increased Intestinal Tumorigenesis in the Double Mutant Mouse Model Multiple Intestinal Neoplasia X Obese via Disturbed Glucose Regulation and Inflammation”

Ha Thi Ngo 1, Ragna Bogen Hetland 1, Unni Cecilie Nygaard 1, Inger-Lise Steffensen 1,*
PMCID: PMC4793134  PMID: 27088011

In the published paper “Genetic and Diet-Induced Obesity Increased Intestinal Tumorigenesis in the Double Mutant Mouse Model Multiple Intestinal Neoplasia X Obese via Disturbed Glucose Regulation and Inflammation” [1] we mistakenly wrote IL-1β instead of IL-6 in Tables  2 and 3. In addition, IL-6 was not included in the text below the tables stating that it was measured by flow cytometer as was TNFα. The corrected tables are presented here.

Table 2.

Associations between various parameters for body weight and glucose, insulin and cytokine levels.

AUC bw Terminal bw  Terminal BMI
R 2 P R 2 P R 2 P
Terminal bw 0.91 <0.001

Terminal BMI 0.59 <0.001 0.62 <0.001

Glucose 0.46 <0.001 0.47 <0.001 0.57 <0.001
6 weeks

Glucose 0.33 <0.001 0.33 <0.001 0.43 <0.001
11 weeks

Insulin 0.34 <0.001 0.32 <0.001 0.48 <0.001

IL-6 0.00 n.s. 0.00 n.s. 0.01 n.s.

TNFα 0.20 0.021 0.23 0.013 0.07 n.s.

Associations between various parameters for body weight (independent variables) and glucose, insulin, and cytokine levels (dependent variables) were examined with simple linear regression (SigmaPlot 12.3, Systat Software Inc., San Jose, CA, USA). This was performed on pairs of end points from all mice from all experimental groups from which individual data could be paired. Body weight (bw) data were evaluated either as area under the curve from week 3 to week 11 (AUC bw), as terminal bw, or as terminal body mass index (BMI) at 11 weeks of age. Nonfasted blood glucose was measured at 6 and 11 weeks of age. Insulin was measured with ELISA, and IL-6 and TNFα were measured with flow cytometer, all in plasma obtained at termination at 11 weeks. R2 = coefficient of determination, n.s. = not statistically significant.

Table 3.

Associations between body weight, glucose, insulin and cytokine levels and the number or diameter of small intestinal tumors.

Number of small intestinal tumors Diameter of small intestinal tumors
R 2 P R 2 P
Diameter of tumors 0.51 <0.001 No. of tumors 0.51 <0.001

AUC bw 0.11 <0.001 AUC bw 0.14 <0.001

Terminal bw 0.05 <0.001 Terminal bw 0.07 <0.001

Terminal BMI 0.08 <0.001 Terminal BMI 0.10 <0.001

Glucose  0.12  <0.001 Glucose  0.09  <0.001
6 weeks 6 weeks

Glucose  0.18  <0.001 Glucose  0.08  <0.001
11 weeks 11 weeks

Insulin 0.03 n.s. Insulin 0.06 n.s.

IL-6 0.00 n.s. IL-6 0.01 n.s.

TNFα 0.09 n.s. TNFα 0.31 0.003

Associations between body weight parameters, glucose, insulin, and cytokine levels (independent variables) and the number or diameter of small intestinal tumors (dependent variables) were examined with simple linear regression (SigmaPlot 12.3, Systat Software Inc., San Jose, CA, USA). This was performed on pairs of end points from all mice from all experimental groups from which individual data could be paired. Number of small intestinal tumors is calculated as number of tumors in each mouse, and tumor diameter is calculated as mean of all tumors in each mouse. Body weight (bw) data were evaluated either as area under the curve from week 3 to week 11 (AUC bw), as terminal bw, or as terminal body mass index (BMI) at 11 weeks of age. Nonfasted blood glucose was measured at 6 and 11 weeks of age. Insulin was measured with ELISA, and IL-6 and TNFα were measured with flow cytometer, all in plasma obtained at termination at 11 weeks. R2 = coefficient of determination, n.s. = not statistically significant.

References

  • 1.Ngo H. T., Hetland R. B., Nygaard U. C., Steffensen I. Genetic and diet-induced obesity increased intestinal tumorigenesis in the double mutant mouse model multiple intestinal neoplasia X obese via disturbed glucose regulation and inflammation. Journal of Obesity. 2015;2015:21. doi: 10.1155/2015/343479.343479 [DOI] [PMC free article] [PubMed] [Google Scholar]

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