Dear Editor:
The article on “Pre-Osteoarthritis: Definition and Diagnosis of an Elusive Clinical Entity” by Ryd et al. is of great interest and importance. The concept and definition of “pre-osteoarthritis” has been a focus of my research program for more than a decade.1 Some of our prior work was summarized in an open access article from 2012 titled “Early Diagnosis to Enable Early Treatment of Pre-Osteoarthritis,” 2 as well as in other articles reflecting presentations at major meetings.3,4 It is exciting to see the coalescence of thought toward defining this intriguing and important entity as we push toward true prevention of osteoarthritis. Congratulations to the workgroup on moving this concept forward.
Sincerely,
Constance R. Chu, MD
Stanford University
References
- 1. Chu CR. Enhanced Clinical Diagnosis of Early Osteoarthritis, R01 AR052784. United States National Institutes of Health, Pittsburgh, PA: June 1, 2005. [Google Scholar]
- 2. Chu CR, Williams AA, Coyle CH, Bowers ME. Early diagnosis to enable early treatment of pre-osteoarthritis. Arthritis Res Ther. 2012;4(3):212. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 3. Chu CR, Millis M, Olson SA. Osteoarthritis: from palliation to prevention: AOA critical issues. J Bone Joint Surg Am. 2014;96(15):e130. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 4. Chu CR, Andriacchi TA. The dance between biology, mechanics, and structure: a systems-based approach to developing osteoarthritis prevention strategies. J Orthop Res. 2015;33(7):939-47. [DOI] [PMC free article] [PubMed] [Google Scholar]