Abstract
A bleeding disorder occurring during labour and affecting mother and foetus is described.
All stages of coagulation were normal until the reaction fibrinogen→fibrin. Either there was some abnormality present in the fibrinogen molecule, or there was an “anticoagulant” acting at this stage.
The abnormality was reversible by protamine sulphate and toluidine blue, but in other respects did not resemble hyperheparinaemia.
Reversibility of a clotting defect by protamine or toluidine blue is not sufficient evidence on which to make a diagnosis of hyperheparinaemia.
Demonstration of a prolonged clotting time occurring in late pregnancy does not necessarily justify the diagnosis of “afibrinogenaemia.”
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BIGGS R., DOUGLAS A. S., MACFARLANE R. G. The action of thromboplastic substances. J Physiol. 1953 Dec 29;122(3):554–569. doi: 10.1113/jphysiol.1953.sp005020. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DRESKIN O. H., ROSENTHAL N. A hemophilia-like disease with prolonged coagulation time and a circulating anticoagulant; report of a case in a female. Blood. 1950 Jan;5(1):46–60. [PubMed] [Google Scholar]
- Jaques L. B., Waters E. T. The identity and origin of the anticoagulant of anaphylactic shock in the dog. J Physiol. 1941 Jun 30;99(4):454–466. doi: 10.1113/jphysiol.1941.sp003915. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KLEIN P. D., SEEGERS W. H. The nature of plasma antithrombin activity. Blood. 1950 Aug;5(8):742–752. [PubMed] [Google Scholar]
- MOORE H. C. Incoagulability of blood after accidental haemorrhage. Br Med J. 1954 Jul 31;2(4882):277–279. doi: 10.1136/bmj.2.4882.277. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SHARP A. A., HOWIE B., BIGGS R., METHUEN D. T. Defibrination syndrome in pregnancy: value of various diagnostic tests. Lancet. 1958 Dec 20;2(7060):1309–1312. doi: 10.1016/s0140-6736(58)90579-8. [DOI] [PubMed] [Google Scholar]