Table 1.
Sensitivity and Specificity of Retinopathy Of Prematurity (ROP) Diagnosis By ROP Experts Based on a Consensus Reference Standard Diagnosis.
| Sensitivity (95% CI) |
P value* | Specificity (95% CI) |
P value* | |||
|---|---|---|---|---|---|---|
| Color Fundus Only |
Color Fundus + FA |
Color Fundus Only |
Color Fundus + FA |
|||
| Stage | ||||||
| Stage 1 or worse | 92.4 (86.7 – 96.1) |
100.0 (97.5 – 100) |
0.063 | - | - | - |
| Stage 2 or worse | 81.3 (73.9 – 87.3) |
99.3 (96.2 – 99.9) |
0.016 | - | - | - |
| Stage 3 or worse | 39.8 (30.5 – 49.7) |
74.1 (64.8 – 82.0) |
0.008 | 63.9 (46.2 – 79.2) |
41.7 (25.5 – 59.2) |
0.453 |
| Zone | ||||||
| Zone I | 47.2 (35.3 – 59.3) |
61.1 (48.9 – 72.4) |
0.219 | 100 (95 – 100) |
100 (95 – 100) |
1.000 |
| Zone II | 97.2 (93 – 99.2) |
97.2 (93 – 99.2) |
1.000 | - | - | - |
| Plus | ||||||
| Pre-Plus or worse | 50.5 (40.3 – 60.7) |
62.6 (52.3 – 72.1) |
0.031 | 73.3 (58.1 – 85.4) |
55.6 (40 – 70.4) |
0.125 |
| Plus | 13.3 (5.1 – 26.8) |
20.0 (9.6 – 34.6) |
1.000 | 87.9 (79.8 – 93.6) |
84.8 (76.2 – 91.3) |
1.000 |
| Category | ||||||
| Mild or worse | 91.7 (85.9 – 95.6) |
100 (97.5 – 100) |
0.0625 | - | - | - |
| Type-2 or worse | 69.4 (61.2 – 76.8) |
86.8 (80.2 – 91.9) |
0.013 | - | - | - |
| Treatment-requiring | 22.2 (13.3 – 33.6) |
40.3 (28.9 – 52.5) |
0.063 | 86.1 (75.9 – 93.1) |
76.4 (64.9 – 85.6) |
0.375 |
FA, Fluorescein angiogram; CI, Confidence Interval.
*
Non-parametric sign test.