Skip to main content
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1960 Sep;13(5):440–447. doi: 10.1136/jcp.13.5.440

FOLIC ACID AND OTHER ABSORPTION TESTS IN LYMPHOSARCOMA, CHRONIC LYMPHOCYTIC LEUKAEMIA, AND SOME RELATED CONDITIONS

W R Pitney 1,2, R A Joske 1,2,*, Norma L Mackinnon 1,2
PMCID: PMC480114  PMID: 13736101

Abstract

An improved folic acid absorption test is described in detail.

Using the folic acid and other absorption tests, a study of intestinal function has been made in eight patients with lymphosarcoma, eight with chronic lymphocytic leukaemia, two with Hodgkin's disease, and one each with reticulum cell sarcoma, Whipple's disease, and macroglobulinaemia. It was found that laboratory evidence of intestinal malabsorption was extremely common in patients with this group of diseases.

The folic acid absorption test was the most sensitive single index of malabsorption of the tests used in this study.

Correlation between the different absorption tests was poor, and there does not appear to be a characteristic biochemical profile of intestinal function in these patients.

Full text

PDF
440

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BENSON J. A., Jr, CULVER P. J., RAGLAND S., JONES C. M., DRUMMEY G. D., BOUGAS E. The d-xylose absorption test in malabsorption syndromes. N Engl J Med. 1957 Feb 21;256(8):335–339. doi: 10.1056/NEJM195702212560802. [DOI] [PubMed] [Google Scholar]
  2. CHANARIN I., ANDERSON B. B., MOLLIN D. L. The absorption of folic acid. Br J Haematol. 1958 Apr;4(2):156–166. doi: 10.1111/j.1365-2141.1958.tb03846.x. [DOI] [PubMed] [Google Scholar]
  3. CHANARIN I., MOLLIN D. L., ANDERSON B. B. The clearance from the plasma of folic acid injected intravenously in normal subjects and patients with megaloblastic anaemia. Br J Haematol. 1958 Oct;4(4):435–446. doi: 10.1111/j.1365-2141.1958.tb06045.x. [DOI] [PubMed] [Google Scholar]
  4. Fairley N. H., Mackie F. P. Clinical and Biochemical Syndrome in Lymphadenoma. Br Med J. 1937 Feb 20;1(3972):375–404.4. doi: 10.1136/bmj.1.3972.375. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. GIRDWOOD R. H. The occurrence of growth factors for Lactobacillus leichmannii; Streptococcus faecalis and Leuconostoc citrovorum in the tissues of pernicious anaemia patients and controls. Biochem J. 1952 Sep;52(1):58–63. doi: 10.1042/bj0520058. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. GORDON R. S., Jr Exudative enteropathy: abnormal permeability of the gastrointestinal tract demonstrable with labelled polyvinylpyrrolidone. Lancet. 1959 Feb 14;1(7068):325–326. doi: 10.1016/s0140-6736(59)90309-5. [DOI] [PubMed] [Google Scholar]
  7. PITNEY W. R., O'SULLIVAN W. J., OWEN J. A. Effect of prednisolone on anaemia associated with macroglobulinemia. Br Med J. 1958 Dec 20;2(5111):1508–1510. doi: 10.1136/bmj.2.5111.1508. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. PITNEY W. R., STOKES J. B. Diagnostic value of radioactive vitamin B12. Australas Ann Med. 1958 May;7(2):126–131. doi: 10.1111/imj.1958.7.2.126. [DOI] [PubMed] [Google Scholar]
  9. SKRIMSHIRE J. F. Lymphoma of the stomach and intestine. Q J Med. 1955 Jul;24(95):203–214. [PubMed] [Google Scholar]
  10. SLEISENGER M. H., ALMY T. P., BARR D. P. The sprue syndrome secondary to lymphoma of the small bowel. Am J Med. 1953 Nov;15(5):666–674. doi: 10.1016/0002-9343(53)90155-7. [DOI] [PubMed] [Google Scholar]
  11. SWENDSEID M. E., BETHELL F. H., BIRD O. D. The concentration of folic acid in leukocytes; observations on normal subjects and persons with leukemia. Cancer Res. 1951 Nov;11(11):864–867. [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES