Abstract
A series of 44 cases of benign Hodgkin's disease is reported. The condition occurs most commonly between the ages of 15 and 35 years and affects men more often than women. The presenting symptom is painless lymphadenopathy, frequently in the neck, and often confined to a single group of nodes. The histological features are the presence of Sternberg-Reed cells in a back-ground of mature lymphocytes intermingled with a small number of reticulum cells. Mitotic figures are usually present only in the Sternberg-Reed cells. The prognosis is good; 93% of cases survive five years and 85% 10 years. About one-quarter of the cases show transition to classical Hodgkin's disease after a period of five or more years and die with widely disseminated Hodgkin's disease. Biopsy-excision followed by radiotherapy is the treatment of choice.
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- BONENFANT J. L. La lympho-réticulose médullaire chronique maligne avec syndrome hodgkinien; paragranulome. Bull Assoc Fr Etud Cancer. 1954;41(2):296–315. [PubMed] [Google Scholar]
- CRAVER L. F., DIAMOND H. D., SOUTHAM C. M. Pregnancy during Hodgkin's disease. Cancer. 1956 Nov-Dec;9(6):1141–1146. doi: 10.1002/1097-0142(195611/12)9:6<1141::aid-cncr2820090612>3.0.co;2-e. [DOI] [PubMed] [Google Scholar]
- HALL C. A., OLSON K. B. Prognosis of the malignant lymphomas. Ann Intern Med. 1956 Apr;44(4):687–706. doi: 10.7326/0003-4819-44-4-687. [DOI] [PubMed] [Google Scholar]
- HARRISON C. V. Benign Hodgkin's disease (Hodgkin's paragranuloma). J Pathol Bacteriol. 1952 Jul;64(3):513–518. doi: 10.1002/path.1700640311. [DOI] [PubMed] [Google Scholar]
- HARTVIGSEN F. B. Hodgkin's disease and pregnancy. Acta radiol. 1955 Oct;44(4):317–324. doi: 10.3109/00016925509171292. [DOI] [PubMed] [Google Scholar]
- HEALY R. J., AMORY H. I., FRIEDMAN M. Hodgkin's disease; a review of two hundred and sixteen cases. Radiology. 1955 Jan;64(1):51–55. doi: 10.1148/64.1.51. [DOI] [PubMed] [Google Scholar]
- HICKS E. B., RAPPAPORT H., WINTER W. J. Follicular lymphoma; a re-evaluation of its position in the scheme of malignant lymphoma, based on a survey of 253 cases. Cancer. 1956 Jul-Aug;9(4):792–821. doi: 10.1002/1097-0142(195607/08)9:4<792::aid-cncr2820090429>3.0.co;2-b. [DOI] [PubMed] [Google Scholar]
- JELLIFFE A. M., THOMSON A. D. The prognosis in Hodgkin's disease. Br J Cancer. 1955 Mar;9(1):21–36. doi: 10.1038/bjc.1955.3. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LUMB G., NEWTON K. A. Prognosis in tumors of lymphoid tissue; an analysis of 602 cases. Cancer. 1957 Sep-Oct;10(5):976–993. doi: 10.1002/1097-0142(195709/10)10:5<976::aid-cncr2820100517>3.0.co;2-w. [DOI] [PubMed] [Google Scholar]
- PETERS M. V., MIDDLEMISS K. C. A study of Hodgkin's disease treated by irradiation. Am J Roentgenol Radium Ther Nucl Med. 1958 Jan;79(1):114–121. [PubMed] [Google Scholar]
- PITCOCK J. A., BAUER W. C., McGAVRAN M. H. Hodgkin's disease in children. A clinicopathological study of 46 cases. Cancer. 1959 Sep-Oct;12:1043–1051. doi: 10.1002/1097-0142(195909/10)12:5<1043::aid-cncr2820120525>3.0.co;2-2. [DOI] [PubMed] [Google Scholar]
- SMETANA H. F., COHEN B. M. Mortality in relation to histologic type in Hodgkin's disease. Blood. 1956 Mar;11(3):211–224. [PubMed] [Google Scholar]
- TRAUTMANN F. Benigne chronische Lymphomatose. Arztl Wochensch. 1954 Nov 19;9(47):1113–concl. [PubMed] [Google Scholar]
- WRIGHT C. J. Hodgkin's paragranuloma. Cancer. 1956 Jul-Aug;9(4):773–777. doi: 10.1002/1097-0142(195607/08)9:4<773::aid-cncr2820090426>3.0.co;2-j. [DOI] [PubMed] [Google Scholar]