Skip to main content
PMC home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1961 Jul;14(4):410–414. doi: 10.1136/jcp.14.4.410

Plasma magnesium in health and disease

Samir Hanna 1,1
PMCID: PMC480244  PMID: 13711276

Abstract

Simpler and more accurate flame spectrophotometric techniques are now available for estimating magnesium. Because of the development of modern electrolyte therapy, cases of hypo-magnesaemia are now encountered more frequently. The condition may lead to dangerous convulsions without sufficient warning. Some causes of hypomagnesaemia and hypermagnesaemia are presented.

Full text

PDF
410

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALCOCK N., MACINTYRE I., RADDE I. The determination of magnesium in biological fluids and tissues by flame spectrophotometry. J Clin Pathol. 1960 Nov;13:506–510. doi: 10.1136/jcp.13.6.506. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BARNES B. A., KRANE S. M., COPE O. Magnesium studies in relation to hyperparathyroidism. J Clin Endocrinol Metab. 1957 Dec;17(12):1407–1421. doi: 10.1210/jcem-17-12-1407. [DOI] [PubMed] [Google Scholar]
  3. CARR M. H., FRANK H. A. Improved method for determination of calcium and magnesium in biologic fluids by EDTA titration. Am J Clin Pathol. 1956 Oct;26(10):1157–1168. doi: 10.1093/ajcp/26.10.1157. [DOI] [PubMed] [Google Scholar]
  4. Cope C. L., Wolff B. The ultrafilterable serum magnesium in hyperthyroidism. Biochem J. 1942 Jun;36(5-6):413–416. doi: 10.1042/bj0360413. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. DAVIS S. A flame photometric method for the determination of plasma magnesium after hydroxyquinoline precipitation. J Biol Chem. 1955 Oct;216(2):643–651. [PubMed] [Google Scholar]
  6. FITZGERALD M. G., FOURMAN P. An experimental study of magnesium deficiency in man. Clin Sci. 1956 Nov;15(4):635–647. [PubMed] [Google Scholar]
  7. FLINK E. B., STUTZMAN F. L., ANDERSON A. R., KONIG T., FRASER R. Magnesium deficiency after prolonged parenteral fluid administration and after chronic alcoholism complicated by delirium tremens. J Lab Clin Med. 1954 Feb;43(2):169–183. [PubMed] [Google Scholar]
  8. HAMBURGER J. Electrolyte disturbances in acute uremia. Clin Chem. 1957 Aug;3(4 Pt 2):332–343. [PubMed] [Google Scholar]
  9. HAMMARSTEN J. F., SMITH W. O. Symptomatic magnesium deficiency in man. N Engl J Med. 1957 May 9;256(19):897–899. doi: 10.1056/NEJM195705092561907. [DOI] [PubMed] [Google Scholar]
  10. HANNA S., HARRISON M., MACINTYRE I., FRASER R. The syndrome of magnesium deficiency in man. Lancet. 1960 Jul 23;2(7143):172–176. doi: 10.1016/s0140-6736(60)91323-4. [DOI] [PubMed] [Google Scholar]
  11. HARMON M. Parathyroid adenoma in a child; report of a case presenting as central nervous system disease and complicated by magnesium deficiency. AMA J Dis Child. 1956 Apr;91(4):313–325. doi: 10.1001/archpedi.1956.02060020315001. [DOI] [PubMed] [Google Scholar]
  12. HUNTER G. Calcium and magnesium content of normal human blood serum. Nature. 1958 Jul 26;182(4630):263–264. doi: 10.1038/182263a0. [DOI] [PubMed] [Google Scholar]
  13. LOWE K. G., HENDERSON J. L., PARK W. W., McGREAL D. A. The idiopathic hypercalcaemic syndromes of infancy. Lancet. 1954 Jul 17;267(6829):101–110. doi: 10.1016/s0140-6736(54)90093-8. [DOI] [PubMed] [Google Scholar]
  14. MACINTYRE I., DAVIDSSON D. The production of secondary potassium depletion, sodium retention, nephrocalcinosis and hypercalcaemia by magnesium deficiency. Biochem J. 1958 Nov;70(3):456–462. doi: 10.1042/bj0700456. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. MACINTYRE I., HANNA S., BOOTH C. C., READ A. E. Intracellular magnesium deficiency in man. Clin Sci. 1961 Jun;20:297–305. [PubMed] [Google Scholar]
  16. MACINTYRE I., WOOTTON I. D. Clinical biochemistry. Annu Rev Biochem. 1960;29:635–648. doi: 10.1146/annurev.bi.29.070160.003223. [DOI] [PubMed] [Google Scholar]
  17. MILNE M. D., MUEHRCKE R. C., AIRD I. Primary aldosteronism. Q J Med. 1957 Jul;26(103):317–333. [PubMed] [Google Scholar]
  18. POTTS J. T., Jr, ROBERTS B. Clinical significance of magnesium deficiency and its relation to parathyroid disease. Am J Med Sci. 1958 Feb;235(2):206–219. doi: 10.1097/00000441-195802000-00014. [DOI] [PubMed] [Google Scholar]
  19. RANDALL R. E., Jr, ROSSMEISL E. C., BLEIFER K. H. Magnesium depletion in man. Ann Intern Med. 1959 Feb;50(2):257–287. doi: 10.7326/0003-4819-50-2-257. [DOI] [PubMed] [Google Scholar]
  20. SCHACHTER D. The fluorometric estimation of magnesium in serum and in urine. J Lab Clin Med. 1959 Nov;54:763–768. [PubMed] [Google Scholar]
  21. SILVERMAN S. H., GARDNER L. I. Ultrafiltration studies on serum magnesium. N Engl J Med. 1954 Jun 3;250(22):938–941. doi: 10.1056/NEJM195406032502204. [DOI] [PubMed] [Google Scholar]
  22. VALLEE B. L., WACKER W. E., ULMER D. D. The magnesium-deficiency tetany syndrome in man. N Engl J Med. 1960 Jan 28;262:155–161. doi: 10.1056/NEJM196001282620401. [DOI] [PubMed] [Google Scholar]
  23. VAN FOSSAN D. D., BAIRD E. E., TEKELL G. S. A simplified flame spectrophotometric method for estimation of magnesium in serum. Am J Clin Pathol. 1959 Apr;31(4):368–370. doi: 10.1093/ajcp/31.4_ts.368. [DOI] [PubMed] [Google Scholar]
  24. WACKER W. E., VALLEE B. L. A study of magnesium metabolism in acute renal failure employing a multichannel flame spectrometer. N Engl J Med. 1957 Dec 26;257(26):1254–1262. doi: 10.1056/NEJM195712262572602. [DOI] [PubMed] [Google Scholar]
  25. Watchorn E., McCance R. A. Inorganic constituents of cerebrospinal fluid: The ultrafiltration of calcium and magnesium from human sera. Biochem J. 1932;26(1):54–64. doi: 10.1042/bj0260054. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES