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. 1961 Sep;14(5):540–542. doi: 10.1136/jcp.14.5.540

Antihaemophilic factor deficiency, capillary defect of von Willebrand type, and idiopathic thrombocytopenia occurring in one family

E K Blackburn 1,2, J M Macfie 1,2, J H Monaghan 1,2, A P M Page 1,2
PMCID: PMC480282  PMID: 13869676

Abstract

Thrombocytopenia of the type found in idiopathic thrombocytopenic purpura is described in a family with a deficiency of antihaemophilic factor, and a capillary abnormality. The propositus (father) has thrombocytopenia and abnormal platelet morphology, together with a plasma deficiency of antihaemophilic factor, but normal capillaries. His two daughters each are deficient in antihaemophilic factor with normal platelets but abnormal capillaries.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BIGGS R., DOUGLAS A. S. The thromboplastin generation test. J Clin Pathol. 1953 Feb;6(1):23–29. doi: 10.1136/jcp.6.1.23. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BRAUNSTEINER H., PAKESCH F. Thrombocytoasthenia and thrombocytopathia-old names and new diseases. Blood. 1956 Nov;11(11):965–976. [PubMed] [Google Scholar]
  3. BRAUNSTEINER H. Thrombopathie und Thrombasthenie. Wien Z Inn Med. 1955 Oct-Nov;36(10-11):421–471. [PubMed] [Google Scholar]
  4. ERLANDSON M., FORT E., LEE R. E., SCHULMAN I., SMITH C. H. Vascular hemophilia; a familial hemorrhagic disease in males and females characterized by combined antihemophilic globulin deficiency and vascular abnormality. Pediatrics. 1956 Sep;18(3):347–361. [PubMed] [Google Scholar]
  5. HORLER A. R., WITTS L. J. Hereditary capillary purpura (Von Willebrand's disease). Q J Med. 1958 Apr;27(106):173–185. [PubMed] [Google Scholar]
  6. INGRAM G. I. Observations in a case of multiple haemostatic defect. Br J Haematol. 1956 Apr;2(2):180–193. doi: 10.1111/j.1365-2141.1956.tb06826.x. [DOI] [PubMed] [Google Scholar]
  7. LARRIEU M. J., SOULIER J. P. Déficit en facteur antihémophilique A chez une fille, associé a un trouble du saignement. Rev Hematol. 1953;8(3):361–370. [PubMed] [Google Scholar]
  8. Merskey C. The Consumption of Prothrombin during Coagulation: The Defect in Haemophilia and Thrombo-Cytopenic Purpura. J Clin Pathol. 1950 May;3(2):130–141. doi: 10.1136/jcp.3.2.130. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. NILSSON I. M., BLOMBACK M., JORPES E., BLOMBACK B., JOHANSSON S. A. Von Willebrand's disease and its correction with human plasma fraction 1-0. Acta Med Scand. 1957 Nov 29;159(3):179–188. doi: 10.1111/j.0954-6820.1957.tb00123.x. [DOI] [PubMed] [Google Scholar]
  10. PERRY S., OPFELL R., BAKER M. Combined deficiencies of PTA and AHG with vascular fragility. Blood. 1960 Aug;16:1184–1198. [PubMed] [Google Scholar]
  11. PITNEY W. R. The assay of antihaemophilic globulin (AHG) in plasma. Br J Haematol. 1956 Jul;2(3):250–264. doi: 10.1111/j.1365-2141.1956.tb06697.x. [DOI] [PubMed] [Google Scholar]
  12. RACCUGLIA G., NEEL J. V. Congenital vascular defect associated with platelet abnormality and antihemophilic factor deficiency. Blood. 1960 Jun;15:807–829. [PubMed] [Google Scholar]
  13. SOULIER J. P., LARRIEU M. J. Syndrome de Willebrand-Jürgens et thrombopathies; étude de 65 cas; essai de classification. Rev Hematol. 1954;9(1):77–122. [PubMed] [Google Scholar]
  14. WILKINSON J. F., NOUR-ELDIN F., ISRAELS M. C. Bridge anticoagulant in von Willebrand's syndrome. Lancet. 1958 Jul 19;2(7038):115–117. doi: 10.1016/s0140-6736(58)92214-1. [DOI] [PubMed] [Google Scholar]

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