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Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1961 Nov;14(6):595–602. doi: 10.1136/jcp.14.6.595

Radio-isotope investigations in primary myeloid metaplasia

A J Bowdler 1
PMCID: PMC480301  PMID: 13872035

Abstract

Chromium-51 and iron-59 studies in patients with primary myeloid metaplasia show that the anaemia of the condition is dependent on depression of marrow activity, aggravated in about one-third of cases by accelerated red cell destruction to which the marrow compensatory response is inadequate. Surface measurements of isotope activity assist in assessing dependence on extramedullary sites for erythropoiesis and in diagnosis. The relevance of these findings to the hypotheses of the pathogenesis of the condition is discussed.

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Selected References

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  1. BAILEY I. S., PRANKERD T. A. Studies in thalassaemia. Br J Haematol. 1958 Apr;4(2):150–155. doi: 10.1111/j.1365-2141.1958.tb03845.x. [DOI] [PubMed] [Google Scholar]
  2. BLOCK M., JACOBSON L. O. Myeloid metaplasia. J Am Med Assoc. 1950 Aug 19;143(16):1390–1396. doi: 10.1001/jama.1950.02910510008002. [DOI] [PubMed] [Google Scholar]
  3. Bowdler A. J., Prankerd T. A. Primary Myeloid Metaplasia. Br Med J. 1961 May 13;1(5236):1352–1358. doi: 10.1136/bmj.1.5236.1352. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. CHAPLIN H., Jr, MOLLISON P. L. Red cell life-span in nephritis and in hepatic cirrhosis. Clin Sci. 1953 Nov;12(4):351–360. [PubMed] [Google Scholar]
  5. CLAMAN M. A., COLLIER W. J. Acute hemolytic anemia associated with myeloid metaplasia of the spleen; report of a case treated by a splenectomy. AMA Arch Intern Med. 1952 Mar;89(3):431–435. doi: 10.1001/archinte.1952.00240030080009. [DOI] [PubMed] [Google Scholar]
  6. CROSBY W. H., AKEROYD J. H. The limit of hemoglobin synthesis in hereditary hemolytic anemia; its relation to the excretion of bile pigment. Am J Med. 1952 Sep;13(3):273–283. doi: 10.1016/0002-9343(52)90282-9. [DOI] [PubMed] [Google Scholar]
  7. Collins D. C. Formation of Bone Marrow in the Suprarenal Gland. Am J Pathol. 1932 Jan;8(1):97–106.1. [PMC free article] [PubMed] [Google Scholar]
  8. DAMESHEK W. Some speculations on the myeloproliferative syndromes. Blood. 1951 Apr;6(4):372–375. [PubMed] [Google Scholar]
  9. DESFORGES J. F., ROSS J. D., MOLONEY W. C. Mechanisms of anemia in leukemia and malignant lymphoma. Am J Med. 1960 Jan;28:69–76. doi: 10.1016/0002-9343(60)90224-2. [DOI] [PubMed] [Google Scholar]
  10. GREEN T. W., CONLEY C. L., ASHBURN L. L., PETERS H. R. Splenectomy for myeloid metaplasia of the spleen. N Engl J Med. 1953 Feb 5;248(6):211–219. doi: 10.1056/NEJM195302052480601. [DOI] [PubMed] [Google Scholar]
  11. HARRIS I. M., MCALISTER J. M., PRANKERD T. A. The relationship of abnormal red cells to the normal spleen. Clin Sci. 1957 May;16(2):223–230. [PubMed] [Google Scholar]
  12. HAYHOE F. G., WHITBY L. Splenic function; a study of the rationale and results of splenectomy in blood disorders. Q J Med. 1955 Oct;24(96):365–391. [PubMed] [Google Scholar]
  13. HUFF R. L., ELMLINGER P. J., GARCIA J. F., ODA J. M., COCKRELL M. C., LAWRENCE J. H. Ferrokinetics in normal persons and in patients having various erythropoietic disorders. J Clin Invest. 1951 Dec;30(122):1512–1526. doi: 10.1172/JCI102562. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. HUTT M. S. R., PINNIGER J. L., WETHERLEY-MEIN G. The myeloproliferative disorders with special reference to myelofibrosis. Blood. 1953 Apr;8(4):295–314. [PubMed] [Google Scholar]
  15. Heller E. L., Lewisohn M. G., Palin W. E. Aleukemic Myelosis: Chronic Nonleukemic Myelosis, Agnogenic Myeloid Metaplasia, Osteosclerosis, Leuko-Erythroblastic Anemia, and Synonymous Designations. Am J Pathol. 1947 May;23(3):327–365. [PMC free article] [PubMed] [Google Scholar]
  16. JOSKE R. A., MCALISTER J. M., PRANKERD T. A. Isotope investigations of red cell production and destruction in chronic renal disease. Clin Sci. 1956 Nov;15(4):511–522. [PubMed] [Google Scholar]
  17. LAWRENCE J. H., BERLIN N. I., HUFF R. L. The nature and treatment of polycythemia; studies on 263 patients. Medicine (Baltimore) 1953 Sep;32(3):323–388. doi: 10.1097/00005792-195309000-00002. [DOI] [PubMed] [Google Scholar]
  18. LEONARD B. J., ISRAELS M. C., WILKINSON J. F. Myelosclerosis; a clinico-pathological study. Q J Med. 1957 Jan;26(101):131–147. [PubMed] [Google Scholar]
  19. NATHAN D. G., BERLIN N. I. Studies of the production and life span of erythrocytes in myeloid metaplasia. Blood. 1959 Jun;14(6):668–682. [PubMed] [Google Scholar]
  20. PANELS in therapy. II. Splenectomy in myeloid metaplasia with myelosclerosis. Blood. 1955 May;10(5):550–554. [PubMed] [Google Scholar]
  21. SCHWARZ E. Extramedullary megakaryocytosis in chronic myelosis. Am J Clin Pathol. 1954 Jun;24(6):629–651. doi: 10.1093/ajcp/24.6.629. [DOI] [PubMed] [Google Scholar]
  22. WEINSTEIN I. M., LEROY G. V. Radioactive sodium chromate for the study of survival of red blood cells. II. The rate of hemolysis in certain hematologic disorders. J Lab Clin Med. 1953 Sep;42(3):368–376. [PubMed] [Google Scholar]

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