Abstract
Sialic acid levels in normal and pathological sera estimated by the improved Svennerholm technique are reported. The increased levels demonstrable in rheumatoid arthritis, cirrhosis, γ myelomata, and macroglobulinaemia are demonstrated as being explicable on the basis of increased production of proteins of normal sialic content.
Tentative reasons are given for the possibility that abnormal binding of sialic acid may occur in nephrotic sera and sera from β globulin myelomata. The latter may be confused with `macroglobulinaemia'.
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Selected References
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- BLIX F. G., GOTTSCHALK A., KLENK E. Proposed nomenclature in the field of neuraminic and sialic acids. Nature. 1957 May 25;179(4569):1088–1088. doi: 10.1038/1791088b0. [DOI] [PubMed] [Google Scholar]
- BOHM P., BAUMEISTER L. Uber Vorkommen und Bestimmung von Neuraminsaure im Fibrin. Klin Wochenschr. 1955 Aug 1;33(29-30):712–713. doi: 10.1007/BF01473285. [DOI] [PubMed] [Google Scholar]
- FRANKLIN E. C., KUNKEL H. G., MULLER-EBERHARD H. J. Two types of gamma-globulin differing in carbohydrate content. Proc Soc Exp Biol Med. 1956 Oct;93(1):146–150. doi: 10.3181/00379727-93-22690. [DOI] [PubMed] [Google Scholar]
- KLENK E., LAUENSTEIN K. Uber die Glykolipoide und Sphingomyeline des Stromas der Pferdeerythrocyten. Hoppe Seylers Z Physiol Chem. 1953;295:164–173. doi: 10.1515/bchm2.1953.295.1.164. [DOI] [PubMed] [Google Scholar]
- SVENNERHOLM L. Quantitative estimation of sialic acids. II. A colorimetric resorcinol-hydrochloric acid method. Biochim Biophys Acta. 1957 Jun;24(3):604–611. doi: 10.1016/0006-3002(57)90254-8. [DOI] [PubMed] [Google Scholar]
- WARREN L. The thiobarbituric acid assay of sialic acids. J Biol Chem. 1959 Aug;234(8):1971–1975. [PubMed] [Google Scholar]
- WERNER I., ODIN L. On the presence of sialic acid in certain glycoproteins and in gangliosides. Acta Soc Med Ups. 1952;57(3-4):230–241. [PubMed] [Google Scholar]