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. 1993 Dec 15;90(24):11618–11622. doi: 10.1073/pnas.90.24.11618

Osteoporosis induced in mice by overproduction of interleukin 4.

D B Lewis 1, H D Liggitt 1, E L Effmann 1, S T Motley 1, S L Teitelbaum 1, K J Jepsen 1, S A Goldstein 1, J Bonadio 1, J Carpenter 1, R M Perlmutter 1
PMCID: PMC48035  PMID: 8265598

Abstract

Osteoporosis is a common disease in which loss of bone mass results in skeletal fragility. The development of therapies for this disorder has been hampered by the lack of a convenient animal model. Here we describe a disorder in bone homeostasis in transgenic mice that inappropriately express the cytokine interleukin 4 (IL-4) under the direction of the lymphocyte-specific proximal promoter for the lck gene. Bone disease in lck-IL-4 mice appeared to result from markedly decreased bone formation by osteoblasts, features strikingly similar to those observed in cases of severe low-turnover human involutional osteoporosis. By 2 months of age, female and male lck-IL-4 mice invariably developed severe osteoporosis of both cortical and trabecular bone. Osteoporosis was observed in two independently derived founder animals, indicating that this phenotype was directly mediated by the IL-4 transgene.

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Selected References

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