Abstract
Two cases are presented in which aplastic anaemia was associated with thymus tumours. In Case 1 the patient had a pancytopenic aplastic anaemia and was treated with A.C.T.H. The marrow showed regeneration at necropsy. The thymoma in this case was unusual as there was thymic regression with fat replacement which may have been related to A.C.T.H. Case 2 was initially of a pure red cell anaemia with but little tendency to produce a leucocytosis in response to infection and was found at necropsy to have a lymphoepithelioma of the thymus. Previously reported cases are reviewed and the role of A.C.T.H. in treatment is discussed.
Full text
PDFImages in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BAKKER P. M. Enkele opmerkingen bij twee gezwellen van de thymus. Ned Tijdschr Geneeskd. 1954 Feb 6;98(6):386–387. [PubMed] [Google Scholar]
- BAYRD E. D., BERNATZ P. E. Benign thymoma and agenesis of erythrocytes. J Am Med Assoc. 1957 Mar 2;163(9):723–727. doi: 10.1001/jama.1957.02970440019006. [DOI] [PubMed] [Google Scholar]
- CHALMERS J. N. M., BOHEIMER K. Pure red-cell anaemia in patients with thymic tumours. Br Med J. 1954 Dec 25;2(4903):1514–1518. doi: 10.1136/bmj.2.4903.1514. [DOI] [PMC free article] [PubMed] [Google Scholar]
- CLARKSON B., PROCKOP D. J. Aregenerative anemia associated with benign thymoma. N Engl J Med. 1958 Aug 7;259(6):253–258. doi: 10.1056/NEJM195808072590601. [DOI] [PubMed] [Google Scholar]
- COUESPEL R., GAILLARD J. A., VAILLANT G. [Tumor of the thymus, anemia and erythroblastic hypoplasia]. J Fr Med Chir Thorac. 1960;14:617–630. [PubMed] [Google Scholar]
- DUNN B. H., FRKOVICH G. Lipomas of the thymus gland with an illustrative case report. Am J Pathol. 1956 Jan-Feb;32(1):41–51. [PMC free article] [PubMed] [Google Scholar]
- FREEMAN Z. Pure red-cell anaemia and thymoma: report of a case. Br Med J. 1960 May 7;1(5183):1390–1392. doi: 10.1136/bmj.1.5183.1390. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GREEN P. Aplastic anaemia associated with thymoma; report of two cases. Can Med Assoc J. 1958 Mar 15;78(6):419–421. [PMC free article] [PubMed] [Google Scholar]
- HODGKINSON R. Blood dyscrasias associated with chloramphenicol. an investigation into the cases in the British Isles. Lancet. 1954 Feb 6;266(6806):285–287. doi: 10.1016/s0140-6736(54)91033-8. [DOI] [PubMed] [Google Scholar]
- JACOBS E. M., HUTTER R. V., POOL J. L., LEY A. B. Benign thymoma and selective erythroid aplasia of the bone marrow. Cancer. 1959 Jan-Feb;12(1):47–57. doi: 10.1002/1097-0142(195901/02)12:1<47::aid-cncr2820120110>3.0.co;2-q. [DOI] [PubMed] [Google Scholar]
- KURREIN F. Pure red cell anaemia coincident with benign thymoma. J Clin Pathol. 1959 Jul;12:319–321. doi: 10.1136/jcp.12.4.319. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LAMBIE A. T., BURROWS B. A., SOMMERS S. C. Clinicopathologic conference; refractory anemia, agammaglobulinemia, and mediastinal tumor. Am J Clin Pathol. 1957 Apr;27(4):444–452. doi: 10.1093/ajcp/27.4.444. [DOI] [PubMed] [Google Scholar]
- PARRY E. H., KILPATRICK G. S., HARDISTY R. M. Red-cell aplasia and benign thymoma; studies on a case responding to prednisone. Br Med J. 1959 May 2;1(5130):1154–1156. doi: 10.1136/bmj.1.5130.1154. [DOI] [PMC free article] [PubMed] [Google Scholar]
- RAMOS A. J. Presentation of case. J Am Med Assoc. 1956 Apr 14;160(15):1317–1319. [PubMed] [Google Scholar]
- ROSS J. F., FINCH S. C., STREET R. B., Jr, STRIEDER J. W. The simultaneous occurrence of benign thymoma and refractory anemia. Blood. 1954 Oct;9(10):935–952. [PubMed] [Google Scholar]
- SCOTT J. L., CARTWRIGHT G. E., WINTROBE M. M. Acquired aplastic anemia: an analysis of thirty-nine cases and review of the pertinent literature. Medicine (Baltimore) 1959 May;38(2):119–172. [PubMed] [Google Scholar]
- SHILLITOE A. J., GOODYEAR J. E. Thymolipoma: a benign tumour of the thymus gland. J Clin Pathol. 1960 Jul;13:297–298. doi: 10.1136/jcp.13.4.297. [DOI] [PMC free article] [PubMed] [Google Scholar]