Abstract
This study is based on the clinical records and post-mortem findings of 264 patients with leukaemia. Gross leukaemic lesions in the gastrointestinal tract were found in 39 patients, an overall incidence of 14·8%. The incidence in all types of acute leukaemia was 18·4%, in chronic leukaemias 9·6%, and in myeloid leukaemia 10·9%. The ileum, stomach, and proximal colon were the sites most commonly affected. Four types of lesion were found: raised leukaemic nodules, leukaemic plaques, diffuse infiltrations with a convoluted brain-like appearance of the mucosal folds, and a multiple leukaemic polyposis. The clinical and pathological features of these lesions are described, and references are given to similar cases reported in the literature.
Full text
PDF








Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BIRNBAUM W., AHLQUIST R. Rectal infections and ulcerations associated with blood dyscrasias. Am J Surg. 1955 Aug;90(2):367–372. doi: 10.1016/0002-9610(55)90770-4. [DOI] [PubMed] [Google Scholar]
- BLACKBURN E. K., DANIEL O. Serious haemorrhage after partial gastrectomy in unsuspected chronic myeloid leukaemia. Br Med J. 1957 Dec 21;2(5059):1476–1476. doi: 10.1136/bmj.2.5059.1476. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BLANK W. A. Anorectal complications in leukemia. Am J Surg. 1955 Nov;90(5):738–741. doi: 10.1016/0002-9610(55)90693-0. [DOI] [PubMed] [Google Scholar]
- BLATT L. J., CHAPMAN I. Multiple colonic polyps of leukemic origin. Dis Colon Rectum. 1960 May-Jun;3:237–240. doi: 10.1007/BF02616560. [DOI] [PubMed] [Google Scholar]
- BLUEFARB S. M. Anorectal complications of acute leukemia simulating lymphopathia venereum. Q Bull Northwest Univ Med Sch. 1957;31(3):198–201. [PMC free article] [PubMed] [Google Scholar]
- BOQUIEN Y., KERNEIS J. P., GUENEL Leucémie lymphoide avec tumeur gastrique terminale apre53s quatre ans et demi d'évolution. Arch Mal Appar Dig Mal Nutr. 1958 Nov;47(11):1217–1226. [PubMed] [Google Scholar]
- CATTAN R., FRUMUSAN P., BENSAUDE A., BREYNAERT P., ISRAEL P., HABIB R. Leucoses aigues et chroniques amanifestations digestives prédominantes. Arch Mal Appar Dig Mal Nutr. 1953 Jul-Aug;42(7-8):904–915. [PubMed] [Google Scholar]
- CAVINS J. A., LEVIN H. S., DAY H. J. Chronic myelogenous leukemia with gastric infiltration; report of a case simulating carcinoma of the stomach. N Engl J Med. 1959 May 28;260(22):1111–1114. doi: 10.1056/NEJM195905282602203. [DOI] [PubMed] [Google Scholar]
- COMOLLI E. Leucemia acuta con manifestazioni tumorali, svelate dall'indagine radiografica, estese a tutto il tubo digerente. Minerva Pediatr. 1949 Nov;1(11):401–409. [PubMed] [Google Scholar]
- CONLEY R. H., WILSON J. A. Chronic leukemic infiltration of the gastric wall simulating peptic ulcer. Minn Med. 1950 Oct;33(10):1004–1008. [PubMed] [Google Scholar]
- CORNES J. S., JONES T. G., FISHER G. B. Gastroduodenal ulceration and massive hemorrhage in patients with leukemia, multiple myeloma, and malignant tumors of lymphoid tissue. Gastroenterology. 1961 Oct;41:337–344. [PubMed] [Google Scholar]
- DEBRAY J., SARAKINOS M. Les localisations digestives des hémopathies malignes. Sang. 1958;29(7):572–590. [PubMed] [Google Scholar]
- GIRARD M., FRAISSE H., NOEL G., GRIVET A. Localisation recto-sigmoïdienne au cours des leucoses lymphoïdes. Lyon Med. 1955 May 29;87(22):525–532. [PubMed] [Google Scholar]
- KOSTER M., BLICKMAN J. R. Maligne lymfoïde gezwellen van de maag. Ned Tijdschr Geneeskd. 1958 Mar 22;102(12):573–576. [PubMed] [Google Scholar]
- LEACH W. B. Acute leukemia: a pathologic study of the causes of death in 157 proved cases. Can Med Assoc J. 1961 Aug 12;85:345–349. [PMC free article] [PubMed] [Google Scholar]
- LEVRAT M., RICHARD M., NORMAND J., ANJOU F. Un cas de localisation rectale d'une leucémie myéloide. Arch Mal Appar Dig Mal Nutr. 1955 Jul-Aug;44(7-8):955–958. [PubMed] [Google Scholar]
- MARKS M. M. Monocytic leukemia: oral and anorectal involvement; report of a case. J Int Coll Surg. 1953 Dec;20(6):750–752. [PubMed] [Google Scholar]
- NAGEL W. Beitrag zur Frage der Magen-Darmveränderungen bei der lymphatischen Liukämie. Zentralbl Allg Pathol. 1952 Feb;88(7):259–262. [PubMed] [Google Scholar]
- NIWAYAMA G., TERPLAN K. A study of peptic ulcer based on necropsy records. Gastroenterology. 1959 Mar;36(3):409–422. [PubMed] [Google Scholar]
- PALMER E. D. Leukemia, gastroduodenal ulcer, and the problem of massive upper gastrointestinal hemorrhage. Cancer. 1955 Jan-Feb;8(1):132–135. doi: 10.1002/1097-0142(1955)8:1<132::aid-cncr2820080118>3.0.co;2-6. [DOI] [PubMed] [Google Scholar]
- PICARD R., HARDY M., LE MEILLET Y. Localisation rectale d'une leucose aiguë. Arch Mal Appar Dig Mal Nutr. 1957 Jun;46(6):571–575. [PubMed] [Google Scholar]
- STOBBE H. Veränderungen am Magen-Darmkanal bei Leukosen. Med Klin. 1958 Mar 28;53(13):497–499. [PubMed] [Google Scholar]
- TOKORO Y. The lesions in other organs in the course of gastroduodenal ulcers (correlation of gastroduodenal ulcers based upon a Histopathological evaluation of background organs). Schweiz Z Pathol Bakteriol. 1958;21(2):504–546. doi: 10.1159/000160402. [DOI] [PubMed] [Google Scholar]
- VACHON A., LEHMANN M., PELLET M., DELAHAYE J. P. Localisation rectale au cours d'une leucémie aiguë. Arch Mal Appar Dig Mal Nutr. 1956 May;45(5):554–556. [PubMed] [Google Scholar]
- VOGEL F. Anorectal pathology in systemic disease: report of a case of leukemia. Am J Gastroenterol. 1960 Oct;34:425–428. [PubMed] [Google Scholar]
- WAHL H. R., HILL J. H. Gastric lesions in Hodgkin's disease and leukemia. Am J Pathol. 1956 Mar-Apr;32(2):235–251. [PMC free article] [PubMed] [Google Scholar]
- WOLMA F. J., Jr, LYNCH J. B. Leukemic infiltration of colon; an unusual cause for massive melena. AMA Arch Surg. 1959 Jan;78(1):71–74. doi: 10.1001/archsurg.1959.04320010075012. [DOI] [PubMed] [Google Scholar]





