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. Author manuscript; available in PMC: 2016 Nov 26.
Published in final edited form as: Nature. 2015 Nov 2;527(7579):539–543. doi: 10.1038/nature15519

Extended Data Figure 4. Stoichiometry determination for α-KG and O2 in FtmOx1 reaction.

Extended Data Figure 4

a, b, Equivalents of endoperoxide products (2 and 3) produced as a function of the ratio of α -KG to iron-loaded FtmOx1 (a) and oxygen to iron-loaded FtmOx1 (b). The quantification was conducted based on the fumitremorgin B (1), compound 2, and compound 3 internal standards. All calculations were based on the concentration of iron-loaded FtmOx1. The experiments were replicated three times and error bars represent s.d.