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. 1962 Nov;15(6):548–551. doi: 10.1136/jcp.15.6.548

Resistance of Salmonella typhi to chloramphenicol

Part II The mechanism of resistance 1

PMCID: PMC480456  PMID: 16810989

Abstract

A study of the action of the culture filtrates of 10 strains of S. typhi resistant to chloramphenicol showed that two of the strains produced an extracellular substance which enabled a strain of S. typhi sensitive to chloramphenicol to grow in a mixture of the filtrate and the antibiotic. A study of the properties of this substance suggested that it was an enzyme.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alexander H. E., Leidy G., Redman W. COMPARISON OF THE ACTION OF STREPTOMYCIN, POLYMYXIN B, AUREOMYCIN AND CHLOROMYCETIN ON H. PERTUSSIS, H. PARAPERTUSSIS, H. INFLUENZAE AND FIVE ENTERIC STRAINS OF GRAM-NEGATIVE BACILLI. J Clin Invest. 1949 Sep;28(5 Pt 1):867–870. doi: 10.1172/JCI102170. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. COLQUHOUN J., WEETCH R. S. Resistance to chloramphenicol developing during treatment of typhoid fever. Lancet. 1950 Nov 25;2(6639):621–623. doi: 10.1016/s0140-6736(50)91585-6. [DOI] [PubMed] [Google Scholar]
  3. CZEKALOWSKI J. W. Penicillin inactivators of bacterial origin. J Pathol Bacteriol. 1950 Jan;62(1):85–102. doi: 10.1002/path.1700620112. [DOI] [PubMed] [Google Scholar]
  4. ERIKSEN K. R., HANSEN D. Observations on the extracellular nature of staphylococcal penicillinase. Acta Pathol Microbiol Scand. 1954;35(2):169–174. doi: 10.1111/j.1699-0463.1954.tb00858.x. [DOI] [PubMed] [Google Scholar]
  5. GOCKE T. M., FINLAND M. Crossresistance to antibiotics; effect of repeated exposure of bacteria to aureomycin, terramycin, chloramphenicol or neomycin on the resistance to all of these antibiotics and to streptomycin and penicillin. J Lab Clin Med. 1951 Nov;38(5):719–735. [PubMed] [Google Scholar]
  6. Gilson B. S., Parker R. F. Staphylococcal Penicillinase: Characteristics of the Enzyme and Its Distribution. J Bacteriol. 1948 Jun;55(6):801–812. doi: 10.1128/jb.55.6.801-812.1948. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Kirby W. M. EXTRACTION OF A HIGHLY POTENT PENICILLIN INACTIVATOR FROM PENICILLIN RESISTANT STAPHYLOCOCCI. Science. 1944 Jun 2;99(2579):452–453. doi: 10.1126/science.99.2579.452. [DOI] [PubMed] [Google Scholar]
  8. MEADS M., HARRIS C. M., HASLAM N. M., CLINE W. A. Chloramphenicol-fastness: development in vivo and experimental production in vitro. J Clin Invest. 1950 Nov;29(11):1474–1479. doi: 10.1172/JCI102387. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. MURGATROYD F. Typhoid treated with chloromycetin. Br Med J. 1949 May 14;1(4610):851–851. doi: 10.1136/bmj.1.4610.851. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. McLean I. W., Schwab J. L., Hillegas A. B., Schlingman A. S. SUSCEPTIBILITY OF MICRO-ORGANISMS TO CHLORAMPHENICOL (CHLOROMYCETIN). J Clin Invest. 1949 Sep;28(5 Pt 1):953–963. doi: 10.1172/JCI102185. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. SCHNEIERSON S. S. Changes in bacterial sensitivity to aureomycin and chloramphenicol in the course of the past three years. J Lab Clin Med. 1952 Jul;40(1):48–57. [PubMed] [Google Scholar]
  12. SMITH G. N., WORREL C. S. The decomposition of chloromycetin (chloramphenicol) by microorganisms. Arch Biochem. 1950 Sep;28(2):232–241. [PubMed] [Google Scholar]
  13. Smith R. M., Joslyn D. A., Gruhzit O. M., McLean I. W., Penner M. A., Ehrlich J. Chloromycetin: Biological Studies. J Bacteriol. 1948 Mar;55(3):425–448. [PMC free article] [PubMed] [Google Scholar]
  14. Spink W. W., Ferris V. PENICILLIN-RESISTANT STAPHYLOCOCCI: MECHANISMS INVOLVED IN THE DEVELOPMENT OF RESISTANCE. J Clin Invest. 1947 May;26(3):379–393. doi: 10.1172/JCI101820. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. VOUREKA A. Bacterial variants in patients treated with chloramphenicol. Lancet. 1951 Jan 6;1(6645):27–28. doi: 10.1016/s0140-6736(51)93498-8. [DOI] [PubMed] [Google Scholar]
  16. WEINER L. M., SWANSON R. E. Chloramphenicol-resistant strains of Salmonella typhosa. I. Induction of morphological, cultural, and antigenic changes. J Bacteriol. 1960 Jun;79:863–868. doi: 10.1128/jb.79.6.863-868.1960. [DOI] [PMC free article] [PubMed] [Google Scholar]

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