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. 2015 Nov 19;139(2):547–562. doi: 10.1093/brain/awv338

Figure 4.

Figure 4

Incorporating network changes into models of the molecular- and cellular-level changes across the Alzheimer’s disease spectrum. Amyloid-PET (A) and hippocampal volume (B) are plotted versus raw score on the 13-item Alzheimer’s Disease Assessment Scale-cognitive subscale within generalized additive models controlling for age, gender, APOE ε4, and total intracranial volume (hippocampal volume only). The deviance explained by the models and P-value for each element displayed is inset. Individual data points (black circles), regression lines (blue), and 95% CIs (grey bands) are displayed. The same analysis performed for network elements (blue, gold, and red solid lines for the posterior DMN, posterior to ventral DMN connection, and ventral DMN to hippocampal connection, respectively) are plotted with amyloid-PET (purple dotted line) and hippocampal volume (green dotted line) (C). For clarity, the 95% CIs are omitted, but can be inspected in the plots for each element individually (see Figs 3A, E, F, 4A and B).