Skip to main content
NCBI home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1963 Jul;16(4):342–350. doi: 10.1136/jcp.16.4.342

A study of the vesical ganglia in children and the relationship to the megaureter megacystis syndrome and Hirschsprung's disease

Sidney Leibowitz 1,1, Martin Bodian 1
PMCID: PMC480575  PMID: 14044036

Abstract

A method for the assay of vesical ganglion cells is described and the number and distribution of the neurones in three normal bladders was studied. Vesical ganglion counts were done in cases of the megaureter-megacystis syndrome, megaureter, bladder neck obstruction, megacystis associated with absent abdominal muscles, Hirschsprung's disease, and lumbar myelomeningocoele. A normal complement of neurones was found in each case.

No evidence was found that the megaureter-megacystis syndrome is due to an agenesis of the peripheral autonomic ganglia similar to that in Hirschsprung's disease. Vesical ganglia were normal in the two cases examined and no clinical association was found between the two conditions in a large series of cases. Moreover, a study of the cell counts suggests that at least some of the reports of such a lesion are based upon an inadequate appreciation of the number and distribution of neurones in the normal urinary tract.

Full text

PDF
342

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BODIAN M., CARTER C. O., WARD B. C. H. Hirschsprung's disease. Lancet. 1951 Feb 10;1(6650):302–309. doi: 10.1016/s0140-6736(51)92290-8. [DOI] [PubMed] [Google Scholar]
  2. BODIAN M. Some observations on the pathology of congenital idiopathic bladder-neck obstruction (Marion's disease). Br J Urol. 1957 Dec;29(4):393–398. doi: 10.1111/j.1464-410x.1957.tb09371.x. [DOI] [PubMed] [Google Scholar]
  3. BOGGS J. D., KIDD J. M. Congenital abnormalities of intestinal innervation; absence of innervation of jejunum, ileum and colon in siblings. Pediatrics. 1958 Feb;21(2):261–266. [PubMed] [Google Scholar]
  4. EDWARDS D. Cine-radiology of congenital bladder-neck obstruction and the megaureter. Br J Urol. 1957 Dec;29(4):410–415. doi: 10.1111/j.1464-410x.1957.tb09374.x. [DOI] [PubMed] [Google Scholar]
  5. HENLEY W. L., HYMAN A. Absent abdominal musculature, genitourinary anomalies, and deficiency in pelvic autonomic nervous system. AMA Am J Dis Child. 1953 Dec;86(6):795–798. doi: 10.1001/archpedi.1953.02050080810012. [DOI] [PubMed] [Google Scholar]
  6. LEWIS E. L., KIMBROUGH J. C. Megaloureter; new concept in treatment. South Med J. 1952 Mar;45(3):171–176. [PubMed] [Google Scholar]
  7. PROSSER C. L., SMITH C. E., MELTON C. E. Conduction of action potentials in the ureter of the rat. Am J Physiol. 1955 Jun;181(3):651–660. doi: 10.1152/ajplegacy.1955.181.3.651. [DOI] [PubMed] [Google Scholar]
  8. RULAND L. Die Bedeutung des peripheren vegetativen Nervensystems für die Entstehung erworbener dystonischer Harnblasen (Megacystis). Z Urol. 1956;49(4):197–207. [PubMed] [Google Scholar]
  9. SHOCKET E., TELOH H. A. Aganglionic megacolon, pheochromocytoma, megaloureter, and neurofibroma; co-occurrence of several neural abnormalities. AMA J Dis Child. 1957 Aug;94(2):185–191. doi: 10.1001/archpedi.1957.04030030079012. [DOI] [PubMed] [Google Scholar]
  10. SWENSON O., FISHER J. H. The relation of megacolon and megaloureter. N Engl J Med. 1955 Dec 29;253(26):1147–1150. doi: 10.1056/NEJM195512292532603. [DOI] [PubMed] [Google Scholar]
  11. SWENSON O., MacMAHON H. E., JAQUES W. E., CAMPBELL J. S. A new concept of the etiology of megaloureters. N Engl J Med. 1952 Jan 10;246(2):41–46. doi: 10.1056/NEJM195201102460201. [DOI] [PubMed] [Google Scholar]
  12. TRAFFORD H. S. Atony of the female bladder; report of four cases. Br Med J. 1959 Jan 17;1(5115):149–151. doi: 10.1136/bmj.1.5115.149. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES