Abstract
Interesting synergism in vitro between a recently introduced antibiotic, colistin methane sulphonate, and sulphonamide drugs is described. The observations were extended to polymyxin B sulphate and sulphonamides with essentially similar results. The combinations are bactericidal at therapeutic levels, the ratio of drugs to one another is not critical, and the effect is present over a fairly wide pH range.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- CARROLL G., MALETTE W. F. The use of colymycin in chronic urinary infections due to Pseudomonas aeuroginosa. J Urol. 1961 Jan;85:86–88. doi: 10.1016/S0022-5347(17)65288-1. [DOI] [PubMed] [Google Scholar]
- HERMAN L. G. Antibiotic sensitivity using pretreated plates. II. A demonstration of inhibitory activity with a low level combination of a sulfonamide and polymyxin B against Proteus species. Antibiot Annu. 1958;6:836–839. [PubMed] [Google Scholar]
- MCMILLAN M., PRICE T. M., MACLAREN D. M., SCOTT G. W. Pseudomonas pyocyanea infection treated with colistin methane sulphonate. Lancet. 1962 Oct 13;2(7259):737–739. doi: 10.1016/s0140-6736(62)90568-8. [DOI] [PubMed] [Google Scholar]
- TAYLOR G., ALLISON H. "Colomycin". Laboratory and clinical investigations. Br Med J. 1962 Jul 21;2(5298):161–163. doi: 10.1136/bmj.2.5298.161. [DOI] [PMC free article] [PubMed] [Google Scholar]