Abstract
In two groups of patients undergoing extracorporeal circulation with hypothermia, changes were found in the coagulation mechanism which were probably due to the dosage of polybrene administered.
The role of heparin and polybrene and the concept of activation of the coagulation mechanism in the production of bleeding after perfusion are discussed.
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Selected References
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- BROWN I. W., Jr, SMITH W. W. Hematologic problems associated with the use of extracorporeal circulation for cardiovascular surgery. Ann Intern Med. 1958 Nov;49(5):1035–1048. doi: 10.7326/0003-4819-49-5-1035. [DOI] [PubMed] [Google Scholar]
- GANS H., SIEGAL D. L., LILLEHEI C. W., KRIVIT W. Problems in hemostasis during open-heart surgery. II. On the hypercoagulability of blood cardiac bypass. Ann Surg. 1962 Jul;156:19–23. doi: 10.1097/00000658-196207000-00005. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KIMURA E. T., YOUNG P. R., EBERT D. M. Further studies on hexadimethrine bromide (polybrene)--an antiheparin agent. Toxicol Appl Pharmacol. 1959 Nov;1:560–575. doi: 10.1016/0041-008x(59)90059-6. [DOI] [PubMed] [Google Scholar]
- MUSTARD J. F. The effect of stored blood transfusions on the platelet levels in patients undergoing surgical procedures. Acta Haematol. 1957 Jul;18(1):80–97. doi: 10.1159/000205304. [DOI] [PubMed] [Google Scholar]
- PERKINS H. A., HARKINS G., GERBODE F., ROLFS M. R., ACRA D. J. Comparison of effects of protamine and polybrene, with special emphasis on the factor VIII (antihemophilic globulin) deficiency induced. J Clin Invest. 1961 Aug;40:1421–1430. doi: 10.1172/JCI104373. [DOI] [PMC free article] [PubMed] [Google Scholar]
- RODMAN N. F., Jr, BARROW E. M., GRAHAM J. B. Diagnosis and control of the hemophilioid states with the partial thromboplastin time (PTT) test. Am J Clin Pathol. 1958 Jun;29(6):525–538. doi: 10.1093/ajcp/29.6.525. [DOI] [PubMed] [Google Scholar]
- ROTHNIE N. G., KINMONTH J. B. Bleeding after perfusion for open heart surgery. Importance of unneutralized heparin and its proper correction. Br Med J. 1960 Jan 9;1(5166):73–78. doi: 10.1136/bmj.1.5166.73. [DOI] [PMC free article] [PubMed] [Google Scholar]
- STEFANINI M. Studies on the hemostatic breakdown during massive replacement transfusions. Am J Med Sci. 1962 Sep;244:298–305. doi: 10.1097/00000441-196209000-00005. [DOI] [PubMed] [Google Scholar]
- YOSHIMURA H., DJERASSI I. Blood coagulation and vascular integrity: effects of heparin. Blood. 1962 Nov;20:602–608. [PubMed] [Google Scholar]