Abstract
Serum leucine aminopeptidase determination was found to be a useful screening procedure for hepatobiliary disease in jaundiced and unjaundiced patients. Values under 1,000 units are of no help in the differential diagnosis of jaundice but values above 1,000 units are highly indicative of biliary obstruction. The differentiation of intra- from extrahepatic obstruction as well as of malignant from benign jaundice cannot generally be established by this single test.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- ARST H. E., MANNING R. T., DELP M. Serum leucine aminopeptidase activity: findings in carcinoma of the pancreas, pregnancy and other disorders. Am J Med Sci. 1959 Nov;238:598–609. [PubMed] [Google Scholar]
- BANKS B. M., PINEDA E. P., GOLDBARG J. A., RUTENBURG A. M. Clinical value of serum leucine aminopeptidase determinations. N Engl J Med. 1960 Dec 22;263:1277–1281. doi: 10.1056/NEJM196012222632503. [DOI] [PubMed] [Google Scholar]
- BRAUN-FALCO O., SALFELD K. Uber das Verhalten der Leucin-Aminopeptidase-Aktivität im Blutserum und Blaseninhalt. I. Untersuchungen an Hautgesunden. Arch Klin Exp Dermatol. 1957;204(5):407–415. [PubMed] [Google Scholar]
- GOEGGEL K. H., CREUTZFELDT W., MURUCAS J. [The behavior of leucine aminopeptidase and other enzymes in the blood serum in liver, biliary and pancreatic diseases]. Dtsch Med Wochenschr. 1960 Sep 30;85:1756–contd. doi: 10.1055/s-0028-1112651. [DOI] [PubMed] [Google Scholar]
- GOLDBARG J. A., RUTENBURG A. M. The colorimetric determination of leucine aminopeptidase in urine and serum of normal subjects and patients with cancer and other diseases. Cancer. 1958 Mar-Apr;11(2):283–291. doi: 10.1002/1097-0142(195803/04)11:2<283::aid-cncr2820110209>3.0.co;2-8. [DOI] [PubMed] [Google Scholar]
- GREEN M. N., TSOU K. C., BRESSLER R., SELIGMAN A. M. The colorimetric determination of leucine aminopeptidase activity with L-leucyl-beta-naphthylamide hydrochloride. Arch Biochem Biophys. 1955 Aug;57(2):458–474. doi: 10.1016/0003-9861(55)90307-6. [DOI] [PubMed] [Google Scholar]
- HAMMOND J. B., ROSENAK B. D., KHOO E. C. The diagnostic value of determinations of serum leucine aminopeptidase concentrations in carcinoma of the pancreas. Am J Dig Dis. 1960 Mar;5:233–245. doi: 10.1007/BF02231093. [DOI] [PubMed] [Google Scholar]
- MILLER A. L., WORSLEY L. Serum leucine aminopeptidase in carcinoma of pancreas and other diseases. Br Med J. 1960 Nov 12;2(5210):1419–1422. doi: 10.1136/bmj.2.5210.1419. [DOI] [PMC free article] [PubMed] [Google Scholar]
- PINEDA E. P., GOLDBARG J. A., BANKS B. M., RUTENBURG A. M. Serum leucine aminopeptidase in pancreatic and hepatobiliary diseases. Gastroenterology. 1960 May;38:698–712. [PubMed] [Google Scholar]
- PINEDA E. P., GOLDBARG J. A., RUTENBURG A. M. Serum enzymes in the diagnosis of pancreatic and hepatic disease in anicteric patients. Surg Forum. 1960;10:249–253. [PubMed] [Google Scholar]
- RENE R. M., MELLINKOFF S. M. Leucine aminopeptidase; its nonspecificity as a test for carcinoma of the pancreas. Am J Dig Dis. 1960 Oct;5:899–904. doi: 10.1007/BF02232191. [DOI] [PubMed] [Google Scholar]
- RUTENBURG A. M., GOLDBARG J. A., PINEDA E. P. Leucine aminopeptidase activity; observations in patients with cancer of the pancreas and other diseases. N Engl J Med. 1958 Sep 4;259(10):469–472. doi: 10.1056/NEJM195809042591003. [DOI] [PubMed] [Google Scholar]
- SHAY H., SUN D. C., SIPLET H. Leucine aminopeptidase: significance of serum elevations in diseases of the hepatobilary-pancreatic system. Am J Dig Dis. 1960 Mar;5:217–232. doi: 10.1007/BF02231092. [DOI] [PubMed] [Google Scholar]
- WINSTEN S., SELLER R. H. Leucine aminopeptidase: an aid to diagnosis. J Albert Einstein Med Cent (Phila) 1961 Jan;9:33–40. [PubMed] [Google Scholar]