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Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1964 Mar;17(2):143–148. doi: 10.1136/jcp.17.2.143

Analysis of `native' cerebrospinal fluid by the polyacrylamide disc electrophoresis technique

V R Cunningham 1
PMCID: PMC480704  PMID: 14149938

Abstract

The polyacrylamide disc electrophoresis technique has been applied to the fractionation of `native' cerebrospinal fluid. Evidence is presented to show that there is an alteration in the protein profile if the fluid is subjected to a concentration stage. A minimum of 22 distinct protein zones have been detected in fluids from patients without structural changes in the nervous system. The method has also been applied to pathological fluids and the differences are discussed.

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  1. KOHN J. A cellulose acetate supporting medium for zone electrophoresis. Clin Chim Acta. 1957 Aug;2(4):297–303. doi: 10.1016/0009-8981(57)90005-0. [DOI] [PubMed] [Google Scholar]

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