Skip to main content
PMC home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1964 Mar;17(2):191–193. doi: 10.1136/jcp.17.2.191

A useful photometric test for the diagnosis of Von Willebrand's disease

H Vainer 1,2, J P Caen 1,2, D Chatelain 1,2, H Michel 1,2
PMCID: PMC480716  PMID: 14149949

Abstract

When small amounts of adenosine diphosphate are added to citrated platelet-rich plasma, the consequent modification of platelets leads to a decrease in optical density. In Von Willebrand's disease the optical density at 610 mμ increases instead of decreasing. This finding is used to study the effects of treatment on this disorder.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BORN G. V. Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature. 1962 Jun 9;194:927–929. doi: 10.1038/194927b0. [DOI] [PubMed] [Google Scholar]
  2. CAEN J., COUSIN C. ["In vivo" disorder of platelet adhesiveness in Willebrand's disease and Glanzmann's thrombasthenias. Trial interpretation]. Nouv Rev Fr Hematol. 1962 Sep-Oct;2:685–694. [PubMed] [Google Scholar]
  3. CORNU P., LARRIEU M. J., CAEN J., BERNARD J. Transfusion studies in von Willebrand's disease: effect on bleeding time and factor VIII. Br J Haematol. 1963 Apr;9:189–202. doi: 10.1111/j.1365-2141.1963.tb05457.x. [DOI] [PubMed] [Google Scholar]
  4. GAARDER A., JONSEN J., LALAND S., HELLEM A., OWREN P. A. Adenosine diphosphate in red cells as a factor in the adhesiveness of human blood platelets. Nature. 1961 Nov 11;192:531–532. doi: 10.1038/192531a0. [DOI] [PubMed] [Google Scholar]
  5. NILSSON I. M., BLOMBACK M., JORPES E., BLOMBACK B., JOHANSSON S. A. Von Willebrand's disease and its correction with human plasma fraction 1-0. Acta Med Scand. 1957 Nov 29;159(3):179–188. doi: 10.1111/j.0954-6820.1957.tb00123.x. [DOI] [PubMed] [Google Scholar]
  6. O'brien J. R. Platelet aggregation: Part I Some effects of the adenosine phosphates, thrombin, and cocaine upon platelet adhesiveness. J Clin Pathol. 1962 Sep;15(5):446–452. doi: 10.1136/jcp.15.5.446. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. SALZMAN E. W. MEASUREMENT OF PLATELET ADHESIVENESS. A SIMPLE IN VITRO TECHNIQUE DEMONSTRATING AN ABNORMALITY IN VON WILLEBRAND'S DISEASE. J Lab Clin Med. 1963 Nov;62:724–735. [PubMed] [Google Scholar]
  8. VAINER H., CAEN J. [Use of a photometric test for the study of the effect of ADP on blood platelets]. Nouv Rev Fr Hematol. 1963 Mar-Apr;3:149–157. [PubMed] [Google Scholar]
  9. ZUCKER M. B. In vitro abnormality of the blood in von Willebrand's disease correctable by normal plasma. Nature. 1963 Feb 9;197:601–602. doi: 10.1038/197601a0. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES