Abstract
Urinary catecholamines, 4-hydroxy-3-methoxymandelic acid (V.M.A.), and metadrenalines have been estimated in 39 cases of proven phaeochromocytoma and in many hypertensive patients without phaeochromocytoma. The variation in excretion of these substances is described and their diagnostic significance discussed. Excretion of free catecholamines and metadrenalines showed a proportionately greater increase than of V.M.A. in patients with a phaeochromocytoma, and estimation of the first two appears to be diagnostically more reliable. Hingerty's method for catecholamines appears to be a satisfactory screening test, provided that 90 μg. is taken as the upper limit of normal, and estimation of metadrenalines is considered to be the best confirmatory test for phaeochromocytoma.
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Selected References
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- CROUT J. R., PISANO J. J., SJOERDSMA A. Urinary excretion of catecholamines and their metabolites in pheochromocytoma. Am Heart J. 1961 Mar;61:375–381. doi: 10.1016/0002-8703(61)90609-3. [DOI] [PubMed] [Google Scholar]
- ELMADJIAN F. Excretion and metabolism of epinephrine. Pharmacol Rev. 1959 Jun;11(2 Pt 2):409–415. [PubMed] [Google Scholar]
- HINGERTY D. Thirty-minutes screening test for phaeochromocytoma. Lancet. 1957 Apr 13;272(6972):766–767. doi: 10.1016/s0140-6736(57)91027-9. [DOI] [PubMed] [Google Scholar]
- HUNTER R. B., MARSHALL P. B., ORAM F. J. CATECHOL AMINE EXCRETION IN NORMAL PERSONS AND IN CASES OF PHAEOCHROMOCYTOMA. Q J Med. 1963 Jul;32:225–242. [PubMed] [Google Scholar]
- LITCHFIELD J. W., PEART W. S. Phaeochromocytoma with normal excretion of adrenaline and noradrenaline. Lancet. 1956 Dec 22;271(6956):1283–1284. doi: 10.1016/s0140-6736(56)91435-0. [DOI] [PubMed] [Google Scholar]
- PISANO J. J. A simple analysis for normetanephrine and metanephrine in urine. Clin Chim Acta. 1960 May;5:406–414. doi: 10.1016/0009-8981(60)90146-7. [DOI] [PubMed] [Google Scholar]
- PISANO J. J., CROUT J. R., ABRAHAM D. Determination of 3-methoxy-4-hydroxymandelic acid in urine. Clin Chim Acta. 1962 Mar;7:285–291. doi: 10.1016/0009-8981(62)90022-0. [DOI] [PubMed] [Google Scholar]
- ROBINSON R., RATCLIFFE J., SMITH P. A screening test for phaeochromocytoma. J Clin Pathol. 1959 Nov;12:541–543. doi: 10.1136/jcp.12.6.541. [DOI] [PMC free article] [PubMed] [Google Scholar]