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. 2015 Nov 13;7(1):638–655. doi: 10.18632/oncotarget.6313

Figure 2. SET expression affects PP2A-mediated p-Ake downregulation and the chemosensitivity of NSCLC cells.

Figure 2

(A) Representative western blot image of the endogenous SET protein expressions in three NSCLC cell lines. (B) Relative mRNA expression level of SET in three NSCLC cell lines. (n = 3) (C) SET knockdown resulted in increasing PP2A activity and decreasing p-Akt expression of NSCLC cells. Upper panel shows results of PP2A activity analysis. Bar: mean, error bar: S.D. (n = 3) Lower panel shows representative image of western blot analysis of NSCLC cells with and without SET knockdown. (D) Ectopic expression of SET decreased paclitaxel-induced cell death. The percentage of apoptotic cells with or without ectopic expression of SET after exposure to paclitaxel at indicated doses for 48 hours was determined by sub-G1 analysis (upper panel). Bar: mean, error bar: S.D. (n = 3).