Abstract
A method is described for the assay of isoniazid in serum and other fluids by diffusion along slopes of Löwenstein-Jensen medium inoculated with tubercle bacilli. The method is convenient, rapid and robust, but is less accurate than diffusion systems for the assay of some other substances.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- COHN M. L., MIDDLEBROOK G., RUSSELL W. F., Jr Combined drug treatment of tuberculosis. I. Prevention of emergence of mutant populations of tubercle bacilli resistant to both streptomycin and isoniazid in vitro. J Clin Invest. 1959 Aug;38(8):1349–1355. doi: 10.1172/JCI103910. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MAHER J. R., WHITNEY J. M., CHAMBERS J. S., STANONIS D. J. The quantitative determination of isoniazid and para-aminosalicylic acid in body fluids. Am Rev Tuberc. 1957 Nov;76(5):852–861. doi: 10.1164/artpd.1957.76.5.852. [DOI] [PubMed] [Google Scholar]
- Mitchison D. A., Holt H. D., Moore S. H. Errors in the Estimation of Streptomycin in Serum. J Clin Pathol. 1949 Aug;2(3):213–216. doi: 10.1136/jcp.2.3.213. [DOI] [PMC free article] [PubMed] [Google Scholar]
- PETERS J. H. Studies on the metabolism of isoniazid. l. Development and application of a fluorometric procedure for measuring isoniazid in blood. Am Rev Respir Dis. 1960 Apr;81:485–497. doi: 10.1164/arrd.1960.81.4.485. [DOI] [PubMed] [Google Scholar]
- SCHMIDT L. H. Measurements of isoniazid in serum. Am Rev Respir Dis. 1962 Oct;86:561–563. doi: 10.1164/arrd.1962.86.4.561. [DOI] [PubMed] [Google Scholar]
- SCHMIEDEL A. Ein Hemmzonenverfahren zur Resistenzbestimmung von Tuberkelbakterien. Beitr Klin Tuberk Spezif Tuberkuloseforsch. 1954;112(6):475–482. [PubMed] [Google Scholar]
- SUNAHARA S., URANO M., LIN H. T., CHEG T. J., JARUMILINDA A. FURTHER OBSERVATIONS ON TRIMODALITY OF FREQUENCY DISTRIBUTION CURVE OF BIOLOGICALLY ACTIVE ISONIAZID BLOOD LEVELS AND "CLINE" INFREQUENCIES OF ALLELES CONTROLLING ISONIAZID INACTIVATION. Acta Tuberc Pneumol Scand. 1963;43:181–195. [PubMed] [Google Scholar]