Table 1.
Summary of UV-4B activity against multiple influenza strains in Differentiated Normal Human Bronchial Epithelial (dNHBE) cells (EpiAirway™).
| Virus Strain | MOI | UV-4B IC90 | Control | IC90 |
|---|---|---|---|---|
| A/California/07/09 (H1N1) | 10−2 CCID50/cell | >320 µM a,e | Oseltamivir | 0.36 µM |
| A/California/12/2012 (H1N1) | 10−4 CCID50/cell | 320 µM c | Ribavirin | <13 µM b |
| 10−3.5 CCID50/cell | 219 µM e | 4.7 µM | ||
| A/Victoria/3/75 (H3N2) | 10−4 CCID50/cell | 440 µM c | Ribavirin | <13 µM b |
| 10−3.5 CCID50/cell | 483 µM e | 5.4 µM | ||
| A/Texas/50/2012 (H3N2) | 10−5 CCID50/cell | 82 µM d | Ribavirin | <13 µM b |
| B/Brisbane/60/2008 | 10−2 CCID50/cell | 200 µM e | Oseltamivir | 3.0 µM |
| B/Florida/4/2006 | 10−2 CCID50/cell | 150 µM e | Oseltamivir | 3.4 µM |
| B/Massachusetts/2/2012 | 10−4 CCID50/cell | 209µM c | Ribavirin | <13 µMb |
| 10−3.5 CCID50/cell | 245 µM c | 4.2 µM | ||
| B/Malaysia/2506/2004 | 10−4 CCID50/cell | >500 µM a,c | Ribavirin | <13 µMb |
| 10−3.5 CCID50/cell | >500 µM a,e | 4.8 µM |
a The IC90 was greater than the highest concentration tested; b The IC90 was less than the lowest concentration tested (13 µM); c Single replicate well per test concentration; d Duplicate test wells in a single assay; e Triplicate test wells in a single assay.