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. 1982 Jan;47(1):11–18. doi: 10.1136/hrt.47.1.11

Assessment of heart neurons in dilated (congestive) cardiomyopathy.

D S Amorim, E G Olsen
PMCID: PMC481089  PMID: 7055507

Abstract

Pathological studies in seven hearts from patients with dilated cardiomyopathy have shown that the number of neurons is significantly reduced in these compared with five hearts from normal subjects. The number of ganglion cells was counted in a strip of right atrial wall between the venae cavae and sectioned serially. The mechanism responsible for the neuronal depopulation in this type of cardiomyopathy could not be determined. Previous viral infection may be causally related. Three hearts of patients suffering from chronic Chagas's heart disease were also studied. Depopulation of neurons was most severe in the hearts with Chagas's disease and less severe in those with dilated cardiomyopathy, though neurons were still significantly reduced in number in the latter compared with normal controls. Despite the lack of a specific, definite cause for the depopulation of neurons, physiological evidence of parasympathetic impairment in patients with dilated cardiomyopathy is in agreement with the pathological findings. It is suggested that on the basis of our findings neuronal depopulation in some patients with dilated cardiomyopathy may be of aetiological significance.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Amorim D. S., Dargie H. J., Heer K., Brown M., Jenner D., Olsen E. G., Richardson P., Goodwin J. F. Is there autonomic impairment in congestive (dilated) cardiomyopathy? Lancet. 1981 Mar 7;1(8219):525–527. doi: 10.1016/s0140-6736(81)92863-4. [DOI] [PubMed] [Google Scholar]
  2. Bolte H. D., Schultheiss P. Immunological results in myocardial diseases. Postgrad Med J. 1978 Jul;54(633):500–504. doi: 10.1136/pgmj.54.633.500. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Böhm G. M. Quantitative study of the intrinsic innervation of the heart in endomyocardial fibrosis and African idiopathic cardiopathies. Rev Inst Med Trop Sao Paulo. 1968 Mar-Apr;10(2):84–87. [PubMed] [Google Scholar]
  4. CHIDSEY C. A., BRAUNWALD E., MORROW A. G. CATECHOLAMINE EXCRETION AND CARDIAC STORES OF NOREPINEPHRINE IN CONGESTIVE HEART FAILURE. Am J Med. 1965 Sep;39:442–451. doi: 10.1016/0002-9343(65)90211-1. [DOI] [PubMed] [Google Scholar]
  5. Cambridge G., MacArthur C. G., Waterson A. P., Goodwin J. F., Oakley C. M. Antibodies to Coxsackie B viruses in congestive cardiomyopathy. Br Heart J. 1979 Jun;41(6):692–696. doi: 10.1136/hrt.41.6.692. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Dos Santos R. B., De Oliveira J. C. Letter: Antibodies to neurons in chronic Chagas' disease. Trans R Soc Trop Med Hyg. 1976;70(2):167–167. doi: 10.1016/0035-9203(76)90195-4. [DOI] [PubMed] [Google Scholar]
  7. Eckberg D. L., Drabinsky M., Braunwald E. Defective cardiac parasympathetic control in patients with heart disease. N Engl J Med. 1971 Oct 14;285(16):877–883. doi: 10.1056/NEJM197110142851602. [DOI] [PubMed] [Google Scholar]
  8. Goodwin J. F. Congestive cardiomyopathy. Introduction, problems and aims of the Multicentre Research Project. Postgrad Med J. 1978 Jul;54(633):431–434. doi: 10.1136/pgmj.54.633.431. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. HIRSCH E. F., BORGHARD-ERDLE A. M. The innervation of the human heart. I. The coronary arteries and the myocardium. Arch Pathol. 1961 Apr;71:384–407. [PubMed] [Google Scholar]
  10. KOEBERLE F. ENTEROMEGALY AND CARDIOMEGALY IN CHAGAS DISEASE. Gut. 1963 Dec;4:399–405. doi: 10.1136/gut.4.4.399. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Kuhn H., Breithardt G., Knieriem H. J., Köhler E., Lösse B., Seipel L., Loogen F. Prognosis and possible presymptomatic manifestations of congestive cardiomyopathy (COCM). Postgrad Med J. 1978 Jul;54(633):451–461. doi: 10.1136/pgmj.54.633.451. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Linden R. J. Function of nerves of the heart. Cardiovasc Res. 1972 Nov;6(6):605–626. doi: 10.1093/cvr/6.6.605. [DOI] [PubMed] [Google Scholar]
  13. MOTT K. E., HAGSTROM J. W. THE PATHOLOGIC LESIONS OF THE CARDIAC AUTONOMIC NERVOUS SYSTEM IN CHRONIC CHAGAS' MYOCARDITIS. Circulation. 1965 Feb;31:273–286. doi: 10.1161/01.cir.31.2.273. [DOI] [PubMed] [Google Scholar]
  14. Oakley C. Diagnosis and natural history of congested (dilated) cardiomyopathies. Postgrad Med J. 1978 Jul;54(633):440–450. doi: 10.1136/pgmj.54.633.440. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Olsen E. G. Pathology of primary cardiomyopathies. Postgrad Med J. 1972 Dec;48(566):732–737. doi: 10.1136/pgmj.48.566.732. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Teixeira A. R., Teixeira M. L., Santos-Buch C. A. The immunology of experimental Chagas' disease. IV. Production of lesions in rabbits similar to those of chronic Chagas' disease in man. Am J Pathol. 1975 Jul;80(1):163–180. [PMC free article] [PubMed] [Google Scholar]
  17. Trezza E., Tucci P. J., Buffollo E., Montenegro M. R. Anticorpos antimiocárdio na doença de Chagas crônica. Correlaço entre a sorologia e a eletrocardiografia. Arq Bras Cardiol. 1975 Jun;28(3):327–344. [PubMed] [Google Scholar]
  18. Wong C. Y., Woodruff J. J., Woodruff J. F. Generation of cytotoxic T lymphocytes during coxsackievirus tb-3 infection. II. Characterization of effector cells and demonstration cytotoxicity against viral-infected myofibers1. J Immunol. 1977 Apr;118(4):1165–1169. [PubMed] [Google Scholar]

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