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. 1982 Feb;47(2):167–172. doi: 10.1136/hrt.47.2.167

Extent of myocardial damage after open-heart surgery assessed from serial plasma enzyme levels in either of two periods (1975 and 1980).

H A Davids, W T Hermens, L Hollaar, A van der Laarse, H A Huysmans
PMCID: PMC481115  PMID: 6977365

Abstract

Perioperative myocardial damage caused by cardiac surgery in 32 patients operated upon in 1980 is quantified in terms of total quantity of alpha-hydroxybutyrate dehydrogenase released from the heart into the circulation, and compared with perioperative myocardial damage in 32 patients operated upon in 1975. In the five year period between 1975 and 1980, various aspects concerning anaesthesia, pharmacological treatment, and myocardial preservation techniques have been subjected to considerable changes. Comparison of calculated myocardial damage in 1980 with that in 1975 shows a general reduction of about 40% in patients having coronary artery bypass grafting, 75% in patients with aortic valve replacement, and 10% in patients with mitral valve replacement.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adams P. X., Cunningham J. N., Jr, Trehan N. K., Brazier J. R., Reed G. E., Spencer F. C. Clinical experience using potassium-induced cardioplegia with hypothermia in aortic valve replacement. J Thorac Cardiovasc Surg. 1978 Apr;75(4):564–568. [PubMed] [Google Scholar]
  2. Brewer D. L., Bilbro R. H., Bartel A. G. Myocardial infarction as a complication of coronary bypass surgery. Circulation. 1973 Jan;47(1):58–64. doi: 10.1161/01.cir.47.1.58. [DOI] [PubMed] [Google Scholar]
  3. Espinoza J., Lipski J., Litwak R., Donoso E., Dack S. New Q waves after coronary artery bypass surgery for angina pectoris. Am J Cardiol. 1974 Feb;33(2):221–224. doi: 10.1016/0002-9149(74)90278-1. [DOI] [PubMed] [Google Scholar]
  4. Flameng W., Borgers M., Daenen W., Thoné F., Coumans W. A., Van der Vusse G. J., Stalpaert G. St. Thomas cardioplegia versus topical cooling: ultrastructural and biochemical studies in humans. Ann Thorac Surg. 1981 Apr;31(4):339–346. doi: 10.1016/s0003-4975(10)60962-9. [DOI] [PubMed] [Google Scholar]
  5. Jynge P., Hearse D. J., de Leiris J., Feuvray D., Braimbridge M. V. Protection of the ischemic myocardium. Ultrastructural, enzymatic, and functional assessment of the efficacy of various cardioplegic infusates. J Thorac Cardiovasc Surg. 1978 Jul;76(1):2–15. [PubMed] [Google Scholar]
  6. Mathey D., Biefield W., Hanrath P., Effert S. Attempt to quantitate relation between cardiac function and infarct size in acute myocardial infarction. Br Heart J. 1974 Mar;36(3):271–279. doi: 10.1136/hrt.36.3.271. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Norris R. M., Whitlock R. M., Barratt-Boyes C., Small C. W. Clinical measurement of myocardial infarct size. Modification of a method for the estimation of total creatine phosphokinase release after myocardial infarction. Circulation. 1975 Apr;51(4):614–620. doi: 10.1161/01.cir.51.4.614. [DOI] [PubMed] [Google Scholar]
  8. ROSALKI S. B., WILKINSON J. H. Reduction of alpha-ketobutyrate by human serum. Nature. 1960 Dec 24;188:1110–1111. doi: 10.1038/1881110a0. [DOI] [PubMed] [Google Scholar]
  9. Rogers W. J., McDaniel H. G., Smith L. R., Mantle J. A., Russel R. O., Jr, Rackley C. E. Correlation of angiographic estimates of myocardial infarct size and accumulated release of creatine kinase MB isoenzyme in man. Circulation. 1977 Aug;56(2):199–205. doi: 10.1161/01.cir.56.2.199. [DOI] [PubMed] [Google Scholar]
  10. Sobel B. E., Bresnahan G. F., Shell W. E., Yoder R. D. Estimation of infarct size in man and its relation to prognosis. Circulation. 1972 Oct;46(4):640–648. doi: 10.1161/01.cir.46.4.640. [DOI] [PubMed] [Google Scholar]
  11. Willems G. M., Muijtjens A. M., Lambi F. H., Hermens W. T. Estimation of circulatory parameters in patients with acute myocardial infarction. Significance for calculation of enzymatic infarct size. Cardiovasc Res. 1979 Oct;13(10):578–587. doi: 10.1093/cvr/13.10.578. [DOI] [PubMed] [Google Scholar]
  12. Witteveen S. A., Hemker H. C., Hollaar L., Hermens W. T. Quantitation of infarct size in man by means of plasma enzyme levels. Br Heart J. 1975 Aug;37(8):795–803. doi: 10.1136/hrt.37.8.795. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. van der Laarse A., Davids H. A., Hollaar L., van der Valk E. J., Witteveen S. A., Hermens W. T. Recognition and quantification of myocardial injury by means of plasma enzyme and isoenzyme activities after cardiac surgery. Br Heart J. 1979 Jun;41(6):660–667. doi: 10.1136/hrt.41.6.660. [DOI] [PMC free article] [PubMed] [Google Scholar]

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