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. 2015 Nov 27;7(2):1529–1543. doi: 10.18632/oncotarget.6414

Figure 5. PPARγ ligand reverses the damaged mitochondrial membrane potential and suppresses ROS production in lal−/− MDSCs.

Figure 5

Bone marrow cells from lal+/+ or lal−/− mice were treated with ethanol (EtOH) or 20 μmol/L 9-HODE for 48 h. A. 9-HODE increased the mitochondrial membrane potential in gated lal−/− Ly6G+CD11b+ cells. Left: Representative dot plot analysis of the JC-1 red and JC-1 green profiles by flow cytometry. Right: Statistical analysis of the mitochondrial membrane potential in Ly6G+CD11b+ cells. B. 9-HODE decreased ROS production in lal−/− Ly6G+CD11b+ cells. Left: Representative analysis of MFI by flow cytometry. Right: Statistical analysis of MFI in Ly6G+CD11b+ cells. Data were expressed as mean ± SD; n = 5∼6. **P < 0.01, *P < 0.05.