Table 6. Cell lines with varying sensitivities to selinexor (IC50 values) have similar XPO1 occupancy values.
| Cell Line | Selinexor IC50 (μM) | 50% Occupancy selinexor (μM) | 90% Occupancy selinexor (μM) | Relative XPO1 protein level per cell |
|---|---|---|---|---|
| MM.1S | 0.02 | 0.07 | 0.48 | 0.5 |
| MV-4–11 | 0.02 | 0.04 | 0.61 | 0.06 |
| HCT-116 | 0.05 | 0.15 | 0.76 | 0.52 |
| HT1080 | 0.07 | 0.44 | 1.35 | 1.74 |
| AML2 | 0.09 | 0.01 | 0.22 | 0.07 |
| AML3 | 0.27 | 0.04 | 0.46 | 0.01 |
| HEL | 0.35 | 0.12 | 0.31 | 0.1 |
| Kasumi-6 | 0.53 | 0.14 | 0.57 | 0.13 |
| THP-1 | 1.06 | 0.1 | 0.94 | 0.44 |
| HT1080 resistant | 2.4 | 0.4 | 1.67 | 1.99 |
| A549 | 3 | 0.09 | 0.56 | 0.3 |
| UCH1 | 7 | 0.15 | 0.65 | 2.18 |
| UCH2 | 30 | 0.27 | 0.89 | 2.84 |
| LS174T | >10 | 0.11 | 0.38 | 0.32 |
| ASPS-KY | >10 | 0.24 | 0.72 | 2.65 |