Skip to main content
NCBI home page
British Heart Journal logoLink to British Heart Journal
. 1982 May;47(5):483–489. doi: 10.1136/hrt.47.5.483

Prevalence of ischaemic heart disease and associations with serum lipoproteins in subjects aged 45 to 64 years. The Speedwell study.

D Bainton, C J Burns-Cox, P C Elwood, B Lewis, N E Miller, K Morgan, P M Sweetnam
PMCID: PMC481166  PMID: 7073910

Abstract

A longitudinal study has been set up to examine the incidence of ischaemic heart disease and its associations with serum lipoproteins including high density lipoprotein cholesterol and its subfractions, certain haemostatic factors, and other "risk' factors. We report here on our pilot study findings. Cross-sectional data were available on 283 men and 68 women aged 45 to 64 representing 85% of the available population randomly selected from the lists of 16 general practitioners. Reproducibility of the measurements of total serum cholesterol, triglyceride, and low density lipoprotein cholesterol was acceptable. The reproducibility of some of the other serum lipid fractions, for example high density lipoprotein cholesterol, was less good, in part because of the small range of the values found for these components. Univariate associations of physical and behavioural characteristics and serum lipoproteins of men and women, with and without ischaemic heart disease, disclosed small and statistically nonsignificant differences except for levels of blood pressure. In particular, there was no significant difference in mean levels of serum high density lipoprotein cholesterol between men with ischaemic heart disease (0.91 mmol/l) and men without it (0.94 mmol/l). In examining our data for the determinants of serum high density lipoprotein cholesterol using a linear multiple regression model, sex, serum high density lipoprotein cholesterol, and very low density lipoprotein triglyceride were the major factors, each individually explaining about 7% of the variance of serum high density lipoprotein cholesterol levels. In addition, alcohol intake and obesity each explained a further 2% of the variance. The experience of the pilot study has led to modifications in the collection of blood samples and the subsequent estimation of lipid fractions.

Full text

PDF
483

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Albers J. J., Warnick G. R., Wiebe D., King P., Steiner P., Smith L., Breckenridge C., Chow A., Kuba K., Weidman S. Multi-laboratory comparison of three heparin-Mn2+ precipitation procedures for estimating cholesterol in high-density lipoprotein. Clin Chem. 1978 Jun;24(6):853–856. [PubMed] [Google Scholar]
  2. Brunner D., Weisbort J., Loebl K., Schwartz S., Altman S., Bearman J. E., Levin S. Serum cholesterol and high density lipoprotein-cholesterol in coronary patients and healthy persons. Atherosclerosis. 1979 May;33(1):9–16. doi: 10.1016/0021-9150(79)90193-x. [DOI] [PubMed] [Google Scholar]
  3. Burstein M., Scholnick H. R., Morfin R. Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions. J Lipid Res. 1970 Nov;11(6):583–595. [PubMed] [Google Scholar]
  4. Carlson L. A., Ericsson M. Quantitative and qualitative serum lipoprotein analysis. Part 1. Studies in healthy men and women. Atherosclerosis. 1975 May-Jun;21(3):417–433. doi: 10.1016/0021-9150(75)90054-4. [DOI] [PubMed] [Google Scholar]
  5. Castelli W. P., Cooper G. R., Doyle J. T., Garcia-Palmieri M., Gordon T., Hames C., Hulley S. B., Kagan A., Kuchmak M., McGee D. Distribution of triglyceride and total, LDL and HDL cholesterol in several populations: a cooperative lipoprotein phenotyping study. J Chronic Dis. 1977 Mar;30(3):147–169. doi: 10.1016/0021-9681(77)90082-0. [DOI] [PubMed] [Google Scholar]
  6. Castelli W. P., Doyle J. T., Gordon T., Hames C. G., Hjortland M. C., Hulley S. B., Kagan A., Zukel W. J. Alcohol and blood lipids. The cooperative lipoprotein phenotyping study. Lancet. 1977 Jul 23;2(8030):153–155. doi: 10.1016/s0140-6736(77)90176-3. [DOI] [PubMed] [Google Scholar]
  7. Eyre J., Hammett F., Miller N. E. A micro-method for the rapid ultracentrifugal separation of human plasma high density lipoprotein subfractions, HDL2 and HDL3. Clin Chim Acta. 1981 Aug 10;114(2-3):225–231. doi: 10.1016/0009-8981(81)90395-8. [DOI] [PubMed] [Google Scholar]
  8. Friedman G. D., Kannel W. B., Dawber T. R., McNamara P. M. Comparison of prevalence, case history and incidence data in assessing the potency of risk factors in coronary heart disease. Am J Epidemiol. 1966 Mar;83(2):366–378. doi: 10.1093/oxfordjournals.aje.a120592. [DOI] [PubMed] [Google Scholar]
  9. Gofman J. W., Young W., Tandy R. Ischemic heart disease, atherosclerosis, and longevity. Circulation. 1966 Oct;34(4):679–697. doi: 10.1161/01.cir.34.4.679. [DOI] [PubMed] [Google Scholar]
  10. Goldbourt U., Medalie J. H. High density lipoprotein cholesterol and incidence of coronary heart disease--the Israeli Ischemic Heart Disease Study. Am J Epidemiol. 1979 Mar;109(3):296–308. doi: 10.1093/oxfordjournals.aje.a112683. [DOI] [PubMed] [Google Scholar]
  11. Gordon T., Castelli W. P., Hjortland M. C., Kannel W. B., Dawber T. R. High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study. Am J Med. 1977 May;62(5):707–714. doi: 10.1016/0002-9343(77)90874-9. [DOI] [PubMed] [Google Scholar]
  12. Khosla T., Lowe C. R. Indices of obesity derived from body weight and height. Br J Prev Soc Med. 1967 Jul;21(3):122–128. doi: 10.1136/jech.21.3.122. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Logan R. L., Riemersma R. A., Thomson M., Oliver M. F., Olsson A. G., Walldius G., Rössner S., Kaijser L., Callmer E., Carlson L. A. Risk factors for ischaemic heart-disease in normal men aged 40. Edinburgh-Stockholm Study. Lancet. 1978 May 6;1(8071):949–954. doi: 10.1016/s0140-6736(78)90246-5. [DOI] [PubMed] [Google Scholar]
  14. Miller G. J., Miller N. E. Plasma-high-density-lipoprotein concentration and development of ischaemic heart-disease. Lancet. 1975 Jan 4;1(7897):16–19. doi: 10.1016/s0140-6736(75)92376-4. [DOI] [PubMed] [Google Scholar]
  15. Miller N. E., Thelle D. S., Forde O. H., Mjos O. D. The Tromsø heart-study. High-density lipoprotein and coronary heart-disease: a prospective case-control study. Lancet. 1977 May 7;1(8019):965–968. doi: 10.1016/s0140-6736(77)92274-7. [DOI] [PubMed] [Google Scholar]
  16. Nichols A. V. Human serum lipoproteins and their interrelationships. Adv Biol Med Phys. 1967;11:109–158. doi: 10.1016/b978-1-4832-3107-5.50008-x. [DOI] [PubMed] [Google Scholar]
  17. Onongbu I. C., Lewis B. Lipoprotein fractionation by a precipitation method. A simple quantitative procedure. Clin Chim Acta. 1976 Sep 20;71(3):397–402. doi: 10.1016/0009-8981(76)90090-5. [DOI] [PubMed] [Google Scholar]
  18. ROSE G. A. The diagnosis of ischaemic heart pain and intermittent claudication in field surveys. Bull World Health Organ. 1962;27:645–658. [PMC free article] [PubMed] [Google Scholar]
  19. Reid D. D., Brett G. Z., Hamilton P. J., Jarrett R. J., Keen H., Rose G. Cardiorespiratory disease and diabetes among middle-aged male Civil Servants. A study of screening and intervention. Lancet. 1974 Mar 23;1(7856):469–473. doi: 10.1016/s0140-6736(74)92783-4. [DOI] [PubMed] [Google Scholar]
  20. Reid D. D., Holland W. W., Rose G. A. An Anglo-American cardiovascular comparison. Lancet. 1967 Dec 30;2(7531):1375–1378. doi: 10.1016/s0140-6736(67)93019-x. [DOI] [PubMed] [Google Scholar]
  21. Steele B. W., Koehler D. F., Azar M. M., Blaszkowski T. P., Kuba K., Dempsey M. E. Enzymatic determinations of cholesterol in high-density-lipoprotein fractions prepared by a precipitation technique. Clin Chem. 1976 Jan;22(1):98–101. [PubMed] [Google Scholar]
  22. Trinder P. Determination of blood glucose using an oxidase-peroxidase system with a non-carcinogenic chromogen. J Clin Pathol. 1969 Mar;22(2):158–161. doi: 10.1136/jcp.22.2.158. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Williams P., Robinson D., Bailey A. High-density lipoprotein and coronary risk factors in normal men. Lancet. 1979 Jan;1(8107):72–75. doi: 10.1016/s0140-6736(79)90063-1. [DOI] [PubMed] [Google Scholar]
  24. Wright B. M., Dore C. F. A random-zero sphygmomanometer. Lancet. 1970 Feb 14;1(7642):337–338. doi: 10.1016/s0140-6736(70)90709-9. [DOI] [PubMed] [Google Scholar]

Articles from British Heart Journal are provided here courtesy of BMJ Publishing Group

RESOURCES