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. 1982 Jun;47(6):539–545. doi: 10.1136/hrt.47.6.539

Effects of histamine type 2 receptor stimulation on myocardial function in normal subjects.

J Watkins, H J Dargie, M J Brown, D M Krikler, C T Dollery
PMCID: PMC481179  PMID: 7082501

Abstract

Myocardial histamine(H)2 receptor stimulation has been studied in six normal men. Since histamine is a potent vasodilator, the haemodynamic effects of histamine infusion were compared with those of nitroprusside at equihypotensive doses, to identify changes in myocardial contractility attributable to vasodilatation. After H1 receptor blockade with mepyramine, subjects received, in single blind crossover fashion, either histamine alone and with the H2 receptor antagonist cimetidine, or nitroprusside alone and with cimetidine. Echocardiographic left ventricular dimensions, plasma catecholamines, blood pressure, and heart rate were measured. The rise in catecholamines suggested similar baroreflex activation by both histamine and nitroprusside. Echo ejection phase indices did not alter significantly after nitroprusside, but histamine caused an increase in percentage fractional shortening from 38.2 +/- 4.1 to 53.5 +/- 3-6% and in mean fibre shortening velocity from 1.31 +/- 0.19 to 1.99 +/- 0.22 cm/s. These changes were both greatly reduced by cimetidine and suggest that H2 receptor stimulation in man causes a direct positive inotropic response.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Black J. W., Duncan W. A., Durant C. J., Ganellin C. R., Parsons E. M. Definition and antagonism of histamine H 2 -receptors. Nature. 1972 Apr 21;236(5347):385–390. doi: 10.1038/236385a0. [DOI] [PubMed] [Google Scholar]
  2. Burland W. L., Duncan W. A., Hesselbo T., Mills J. G., Sharpe P. C., Haggie S. J., Wyllie J. H. Pharmacological evaluation of cimetidine, a new histamine H2-receptor antagonist, in healthy man. Br J Clin Pharmacol. 1975 Dec;2(6):481–486. doi: 10.1111/j.1365-2125.1975.tb00564.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Cooper R. H., O'Rourke R. A., Karliner J. S., Peterson K. L., Leopold G. R. Comparison of ultrasound and cineangiographic measurements of the mean rate of circumferential fiber shortening in man. Circulation. 1972 Nov;46(5):914–923. doi: 10.1161/01.cir.46.5.914. [DOI] [PubMed] [Google Scholar]
  4. Da Prada M., Zürcher Simultaneous radioenzymatic determination of plasma and tissue adrenaline, noradrenaline and dopamine within the femtomole range. Life Sci. 1976 Oct 15;19(8):1161–1174. doi: 10.1016/0024-3205(76)90251-4. [DOI] [PubMed] [Google Scholar]
  5. Eyre P., Wells P. W. Histamine H2-receptors modulate systemic anaphylaxis: a dual cardiovascular action of histamine in calves. Br J Pharmacol. 1973 Oct;49(2):364–367. doi: 10.1111/j.1476-5381.1973.tb08385.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Gibson D. G. Use of M-mode echocardiography in clinical pharmacology. Br J Clin Pharmacol. 1979 May;7(5):443–449. doi: 10.1111/j.1365-2125.1979.tb00984.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Jefferys D. B., Vale J. A. Cimetidine and bradycardia. Lancet. 1978 Apr 15;1(8068):828–828. doi: 10.1016/s0140-6736(78)93035-0. [DOI] [PubMed] [Google Scholar]
  8. Koch-Weser J. Vasodilator drugs in the treatment of hypertension. Arch Intern Med. 1974 Jun;133(6):1017–1027. [PubMed] [Google Scholar]
  9. Levi R., Allan G., Zavecz J. H. Cardiac histamine receptors. Fed Proc. 1976 Jun;35(8):1942–1947. [PubMed] [Google Scholar]
  10. Levi R., Capurro N., Lee C. H. Pharmacological characterization of cardiac histamine receptors: sensitivity to H1-and H2-receptor agonists and antagonists. Eur J Pharmacol. 1975 Feb;30(2):328–335. doi: 10.1016/0014-2999(75)90117-x. [DOI] [PubMed] [Google Scholar]
  11. Ligumsky M., Shochina M., Rachmilewitz D. Cimetidine and arrhythmia suppression. Ann Intern Med. 1978 Dec;89(6):1008–1009. doi: 10.7326/0003-4819-89-6-1008. [DOI] [PubMed] [Google Scholar]
  12. Mahon W. A., Kolton M. Hypotension after intravenous cimetidine. Lancet. 1978 Apr 15;1(8068):828–828. doi: 10.1016/s0140-6736(78)93034-9. [DOI] [PubMed] [Google Scholar]
  13. Owen D. A. Histamine receptors in the cardiovascular. Gen Pharmacol. 1977;8(3):141–156. doi: 10.1016/0306-3623(77)90043-x. [DOI] [PubMed] [Google Scholar]
  14. Parsons M. E., Owen D. A., Ganellin C. R., Durant G. J. Dimaprit -(S-[3-(N,N-dimethylamino)prophyl]isothiourea) - a highly specific histamine H2 -receptor agonist. Part 1. Pharmacology. Agents Actions. 1977 Mar;7(1):31–37. doi: 10.1007/BF01964878. [DOI] [PubMed] [Google Scholar]
  15. Popp R. L., Filly K., Brown O. R., Harrison D. C. Effect of transducer placement on echocardiographic measurement of left ventricular dimensions. Am J Cardiol. 1975 Apr;35(4):537–540. doi: 10.1016/0002-9149(75)90837-1. [DOI] [PubMed] [Google Scholar]
  16. Reding P., Devroede C., Barbier P. Bradycardia after cimetidine. Lancet. 1977 Dec 10;2(8050):1227–1227. doi: 10.1016/s0140-6736(77)90462-7. [DOI] [PubMed] [Google Scholar]
  17. SHARPEY-SCHAFER E. P., GINSBURG J. Humoral agents and venous tone. Effects of catecholamines, 5-hydroxytryptamine, histamine, and nitritex. Lancet. 1962 Dec 29;2(7270):1337–1340. doi: 10.1016/s0140-6736(62)91018-8. [DOI] [PubMed] [Google Scholar]
  18. Schentag J. J., Cerra F. B., Calleri G., DeGlopper E., Rose J. Q., Bernhard H. Pharmacokinetic and clinical studies in patients with cimetidine-associated mental confusion. Lancet. 1979 Jan 27;1(8109):177–181. doi: 10.1016/s0140-6736(79)90578-6. [DOI] [PubMed] [Google Scholar]
  19. Stefadouros M. A., Canedo M. I. Reproducibility of echocardiographic estimates of left ventricular dimensions. Br Heart J. 1977 Apr;39(4):390–398. doi: 10.1136/hrt.39.4.390. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Stefadouros M. A., El Shahawy M., Stefadouros F., Witham A. C. The effect of upright tilt on the volume of the failing human left ventricle. Am Heart J. 1975 Dec;90(6):735–743. doi: 10.1016/0002-8703(75)90463-9. [DOI] [PubMed] [Google Scholar]
  21. Watkins J., FitzGerald G., Zamboulis C., Brown M. J., Dollery C. T. Absence of opiate and histamine H2 receptor-mediated effects of clonidine. Clin Pharmacol Ther. 1980 Nov;28(5):605–610. doi: 10.1038/clpt.1980.210. [DOI] [PubMed] [Google Scholar]
  22. Wollemann M., Papp J. G. Blockade by cimetidine of the effects of histamine on adenylate cyclase activity, spontaneous rate and contractility in the developing praenatal heart [proceedings]. Agents Actions. 1979 Apr;9(1):29–30. doi: 10.1007/BF02024094. [DOI] [PubMed] [Google Scholar]
  23. Woods J. R., Jr, Brinkman C. R., Dandavino A., Murayama K., Assali N. S. Action of histamine and H1 and H2 blockers on the cardiopulmonary circulation. Am J Physiol. 1977 Jan;232(1):H73–H78. doi: 10.1152/ajpheart.1977.232.1.H73. [DOI] [PubMed] [Google Scholar]
  24. Yamaguchi N., de Champlain J., Nadeau R. Correlation between the response of the heart to sympathetic stimulation and the release of endogenous catecholamines into the coronary sinus of the dog. Circ Res. 1975 May;36(5):662–668. doi: 10.1161/01.res.36.5.662. [DOI] [PubMed] [Google Scholar]

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