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. 2016 Jan 4;6(1):1. doi: 10.3390/metabo6010001

Figure 3.

Figure 3

Effect of defatting condition on metabolic flux distribution. Numbers on horizontal axis correspond to reaction numbers shown in Table 2. Values shown are calculated using the MFA model with averaged measured fluxes in each group as input. (A) Fluxes for steatotic HepG2 cells during defatting under normoxic conditions (21% O2 v/v) in basal medium (DMEM) vs. medium supplemented with defatting agents (Defat). Lean controls are for cells that were never made steatotic; (B) Fluxes for steatotic HepG2 cells during defatting in medium supplemented with defatting agents under normoxic (21% O2 v/v) vs. hyperoxic (90% O2 v/v) conditions. Lean controls are for cells that were never made steatotic.