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British Heart Journal logoLink to British Heart Journal
. 1983 Apr;49(4):388–392. doi: 10.1136/hrt.49.4.388

Regional variation of left ventricular transit time in normal ventricles and those with abnormalities of contraction.

S Walton, N J Brown, P H Jarritt, P J Ell, R W Emanuel
PMCID: PMC481319  PMID: 6830673

Abstract

Thirty-three subjects were studied by first pass radionuclide angiography. The extrapolated monoexponential tracer washout slopes from septal, lateral, and apical segments of the left ventricle were measured. In 13 subjects with normal left ventricles, as assessed by ejection fraction estimation and phase analysis, there was no difference between septal and lateral segments but, in each case, apical washout was significantly prolonged. In 20 subjects with abnormal ventricles washouts were, in general, slower than those of the normal ventricles. Apical washout was still the slowest but the difference between base and apex was less pronounced. In contrast to the normal ventricles, differences appeared between septal and lateral segments. The left ventricle is a poor mixing chamber. Pools of relative stasis exist at the apex of both normal and abnormal ventricles and within the body of the chamber in the latter.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bartle S. H., Sanmarco M. E. Measurement of left ventricular volume by biplane angiocardiography and indicator-washout techniques: a comparison in the canine heart. Circ Res. 1966 Aug;19(2):295–306. doi: 10.1161/01.res.19.2.295. [DOI] [PubMed] [Google Scholar]
  2. Bassingthwaighte J. B., Knopp T. J., Anderson D. U. Flow estimation by indicator dilution (bolus injection). Circ Res. 1970 Aug;27(2):277–291. doi: 10.1161/01.res.27.2.277. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Boyle J., 3rd Indicator mixing in the left heart and reexamination of mean circulation time. J Appl Physiol. 1974 Oct;37(4):541–546. doi: 10.1152/jappl.1974.37.4.541. [DOI] [PubMed] [Google Scholar]
  4. Carleton R. A., Bowyer A. F., Graettinger J. S. Overestimation of left ventricular volume by the indicator dilution technique. Circ Res. 1966 Mar;18(3):248–256. doi: 10.1161/01.res.18.3.248. [DOI] [PubMed] [Google Scholar]
  5. Castellana F. S., Snapinn S. M., Tam S. Y., Case R. B. Inlet and intrachamber concentration distributions in tracer studies of the canine central circulation and their relation to the isotope dilution residue function. Circ Res. 1980 Jul;47(1):10–20. doi: 10.1161/01.res.47.1.10. [DOI] [PubMed] [Google Scholar]
  6. IRISAWA H., WILSON M. F., RUSHMER R. F. Left ventricle as a mixing chamber. Circ Res. 1960 Jan;8:183–187. doi: 10.1161/01.res.8.1.183. [DOI] [PubMed] [Google Scholar]
  7. Links J. M., Douglass K. H., Wagner H. N., Jr Patterns of ventricular emptying by Fourier analysis of gated blood-pool studies. J Nucl Med. 1980 Oct;21(10):978–982. [PubMed] [Google Scholar]
  8. MENA I., THOMSEN P., BENNETT L. R. DETERMINATION OF CORONARY BLOOD FLOW INDEX BY EXTERNAL SCINTILLATION DETECTION. J Nucl Med. 1963 Jul;4:259–276. [PubMed] [Google Scholar]
  9. Pavek E., Pavek K., Boska D. Mixing and observation errors in indicator-dilution studies. J Appl Physiol. 1970 Jun;28(6):733–740. doi: 10.1152/jappl.1970.28.6.733. [DOI] [PubMed] [Google Scholar]
  10. Petrle M., Avasthey P. Some problems in the estimation of the end-diastolic volume of the ventricle by dye dilution techniques. Cardiovasc Res. 1968 Apr;2(2):193–198. doi: 10.1093/cvr/2.2.193. [DOI] [PubMed] [Google Scholar]
  11. ROLETT E. L., SHERMAN H., GORLIN R. MEASUREMENT OF LEFT VENTRICULAR VOLUME BY THERMODILUTION: AN APPRAISAL OF TECHNICAL ERRORS. J Appl Physiol. 1964 Nov;19:1164–1174. doi: 10.1152/jappl.1964.19.6.1164. [DOI] [PubMed] [Google Scholar]
  12. SWAN H. J., BECK W. Ventricular nonmixing as a source of error in the estimation of ventricular volume by the indicator-dilution technic. Circ Res. 1960 Sep;8:989–998. doi: 10.1161/01.res.8.5.989. [DOI] [PubMed] [Google Scholar]
  13. Walton S., Yiannikas J., Jarritt P. H., Brown N. J., Swanton R. H., Ell P. J. Phasic abnormalities of left ventricular emptying in coronary artery disease. Br Heart J. 1981 Sep;46(3):245–253. doi: 10.1136/hrt.46.3.245. [DOI] [PMC free article] [PubMed] [Google Scholar]

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