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. 2016 Jan 29;5:82–92. doi: 10.1016/j.ebiom.2016.01.031

Fig. 5.

Fig. 5

Pgam5 KO mice are resistant to high-fat-diet-induced obesity. (a) Representative picture of 16-week-old mice that were fed a high-fat diet (HFD) for 11 weeks. (b) Body weights of WT and Pgam5 KO mice that were fed a HFD (n = 5). (c and d) Tissue weight ratio-normalized body weights of WT and Pgam5 KO mice under CD (n = 4) (c) or HFD for 12 weeks (n = 8) (d). (e) Representative gross image of BAT and liver from WT and Pgam5 KO mice that were fed a HFD for 12 weeks. (f) Representative H&E staining of the indicated fat sections from WT and Pgam5 KO mice that were fed a HFD for 7 weeks. Scale bars, 100 μm. (g and h) GTT (g) in WT and Pgam5 KO mice that were fed a HFD for 12 weeks (n = 5) and ITT (h) in WT and Pgam5 KO mice that were fed a HFD for 8 weeks (n = 6). (i and j) Oxygen consumption of male 9-week-old WT and Pgam5 KO mice under CD (n = 4) (i) and 16-week-old WT and Pgam5 KO mice that were fed a HFD for 12 weeks (n = 4) (j). Data are expressed as the mean ± SEM, *p < 0.05, **p < 0.01, ***p < 0.001; unpaired Student's t-test (c, d, i and j), two-way ANOVA/Bonferroni post-test (b, g, and h). BAT, brown adipose tissue; iWAT, inguinal white adipose tissue; eWAT, epididymal white adipose tissue.