Skip to main content
NCBI home page
British Heart Journal logoLink to British Heart Journal
. 1985 Jan;53(1):16–24. doi: 10.1136/hrt.53.1.16

Prognostic significance of left ventricular ejection fraction after acute myocardial infarction. A bedside radionuclide study.

M J Kelly, P L Thompson, M F Quinlan
PMCID: PMC481715  PMID: 3966947

Abstract

The prognostic significance of left ventricular ejection fraction measurements obtained at the bedside was assessed in 171 patients as soon as possible after acute myocardial infarction. Ejection fraction was measured with a radionuclide first pass portable probe method within a mean of 24 hours of the onset of major symptoms. The results were related prospectively to the subsequent incidence of ventricular fibrillation in hospital, and to hospital and postdischarge deaths in a mean follow up period of 15 (range 9-21) months. All eight episodes of primary ventricular fibrillation, all 12 deaths due to pump failure in hospital, and also 12 out of 13 postdischarge deaths occurred in that minority of 81 patients whose initial postinfarction left ventricular ejection fraction was less than 0.35. Multivariate correlation with clinical, enzymatic, and electrocardiographic indicators of myocardial infarction showed that the prognostic significance of these indicators could largely be explained by their association with low left ventricular ejection fractions. Left ventricular ejection fraction measured within the initial 24 hours after acute myocardial infarction predicts prognosis throughout the subsequent year.

Full text

PDF
16

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Berger H. J., Zaret B. L. Nuclear cardiology (second of two parts). N Engl J Med. 1981 Oct 8;305(15):855–865. doi: 10.1056/NEJM198110083051504. [DOI] [PubMed] [Google Scholar]
  2. Berndt T., Alderman E. L., Wasnich R., Hsieh S. C., Van Dyke D., Harrison D. C. Evaluation of portable radionuclide method for measurement of left ventricular ejection fraction and cardiac output. J Nucl Med. 1975 Apr;16(4):289–292. [PubMed] [Google Scholar]
  3. Borer J. S., Rosing D. R., Miller R. H., Stark R. M., Kent K. M., Bacharach S. L., Green M. V., Lake C. R., Cohen H., Holmes D. Natural history of left ventricular function during 1 year after acute myocardial infarction: comparison with clinical, electrocardiographic and biochemical determinations. Am J Cardiol. 1980 Jul;46(1):1–12. doi: 10.1016/0002-9149(80)90598-6. [DOI] [PubMed] [Google Scholar]
  4. Braat S. H., de Zwaan C., Brugada P., Wellens H. J. Value of left ventricular ejection fraction in extensive anterior infarction to predict development of ventricular tachycardia. Am J Cardiol. 1983 Oct 1;52(7):686–689. doi: 10.1016/0002-9149(83)90398-3. [DOI] [PubMed] [Google Scholar]
  5. Dewhurst N. G., Muir A. L. Comparative prognostic value of radionuclide ventriculography at rest and during exercise in 100 patients after first myocardial infarction. Br Heart J. 1983 Feb;49(2):111–121. doi: 10.1136/hrt.49.2.111. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Groch M. W., Gottlieb S., Mallon S. M., Miale A., Jr A new dual-probe system for the rapid bedside assessment of left ventricular function. J Nucl Med. 1976 Oct;17(10):930–936. [PubMed] [Google Scholar]
  7. Gross H., Vaid A. K., Cohen M. V. Prognosis in patients rejected for coronary revascularization surgery. Am J Med. 1978 Jan;64(1):9–20. doi: 10.1016/0002-9343(78)90174-2. [DOI] [PubMed] [Google Scholar]
  8. Henning H., Schelbert H., Crawford M. H., Karliner J. S., Ashburn W., O'Rourke R. A. Left ventricular performance assessed by radionuclide angiocardiography and echocardiography in patients with previous myocardial infarction. Circulation. 1975 Dec;52(6):1069–1075. doi: 10.1161/01.cir.52.6.1069. [DOI] [PubMed] [Google Scholar]
  9. Kostuk W. J., Ehsani A. A., Karliner J. S., Ashburn W. L., Peterson K. L., Ross J., Jr, Sobel B. E. Left ventricular performance after myocardial infarction assessed by radioisotope angiocardiography. Circulation. 1973 Feb;47(2):242–249. doi: 10.1161/01.cir.47.2.242. [DOI] [PubMed] [Google Scholar]
  10. Nelson G. R., Cohn P. F., Gorlin R. Prognosis in medically-treated coronary artery disease: influence of ejection fraction compared to other parameters. Circulation. 1975 Sep;52(3):408–412. doi: 10.1161/01.cir.52.3.408. [DOI] [PubMed] [Google Scholar]
  11. Norris R. M., Brandt P. W., Caughey D. E., Lee A. J., Scott P. J. A new coronary prognostic index. Lancet. 1969 Feb 8;1(7589):274–278. doi: 10.1016/s0140-6736(69)91035-6. [DOI] [PubMed] [Google Scholar]
  12. Pole D. J., Thompson P. L., Woodings T. L., McCall M. G., Reader R. Acute myocardial infarction: one year follow-up of 1138 cases from the Perth Community Coronary Register. Aust N Z J Med. 1976 Oct;6(5):437–440. doi: 10.1111/j.1445-5994.1976.tb03031.x. [DOI] [PubMed] [Google Scholar]
  13. Rigo P., Murray M., Strauss H. W., Taylor D., Kelly D., Weisfeldt M., Pitt B. Left ventricular function in acute myocardial infarction evaluation by gated scintiphotography. Circulation. 1974 Oct;50(4):678–684. doi: 10.1161/01.cir.50.4.678. [DOI] [PubMed] [Google Scholar]
  14. Schelbert H. R., Henning H., Ashburn W. L., Verba J. W., Karliner J. S., O'Rourke R. A. Serial measurements of left ventricular ejection fraction by radionuclide angiography early and late after myocardial infarction. Am J Cardiol. 1976 Oct;38(4):407–415. doi: 10.1016/0002-9149(76)90455-0. [DOI] [PubMed] [Google Scholar]
  15. Schulze R. A., Jr, Rouleau J., Rigo P., Bowers S., Strauss H. W., Pitt B. Ventricular arrhythmias in the late hospital phase of acute myocardial infarction. Relation to left ventricular function detected by gated cardiac blood pool scanning. Circulation. 1975 Dec;52(6):1006–1011. doi: 10.1161/01.cir.52.6.1006. [DOI] [PubMed] [Google Scholar]
  16. Schulze R. A., Jr, Strauss H. W., Pitt B. Sudden death in the year following myocardial infarction. Relation to ventricular premature contractions in the late hospitals phase and left ventricular ejection fraction. Am J Med. 1977 Feb;62(2):192–199. doi: 10.1016/0002-9343(77)90314-x. [DOI] [PubMed] [Google Scholar]
  17. Shah P. K., Pichler M., Berman D. S., Singh B. N., Swan H. J. Left ventricular ejection fraction determined by radionuclide ventriculography in early stages of first transmural myocardial infarction. Relation to short-term prognosis. Am J Cardiol. 1980 Mar;45(3):542–546. doi: 10.1016/s0002-9149(80)80002-6. [DOI] [PubMed] [Google Scholar]
  18. Steele P. P., Van Dyke D., Trow R. S., Anger H. O., Davies H. Simple and safe bedside method for serial measurement of left ventricular ejection fraction, cardiac output, and pulmonary blood volume. Br Heart J. 1974 Feb;36(2):122–131. doi: 10.1136/hrt.36.2.122. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Steele P., Kirch D., Matthews M., Davies H. Measurement of left heart ejection fraction and end-diastolic volume by a computerized, scintigraphic technique using a wedged pulmonary arterial catheter. Am J Cardiol. 1974 Aug;34(2):179–186. doi: 10.1016/0002-9149(74)90197-0. [DOI] [PubMed] [Google Scholar]
  20. Strauss H. W., Pitt B. Evaluation of cardiac function and structure with radioactive tracer techniques. Circulation. 1978 Apr;57(4):645–654. doi: 10.1161/01.cir.57.4.645. [DOI] [PubMed] [Google Scholar]
  21. Twieg D. B., Stokely E. M., Parkey R. W., Willerson J. T., Nardizzi L. R. Effects of noise on the determination of ejection fraction from left ventricular time-activity curves. J Nucl Med. 1977 Feb;18(2):180–182. [PubMed] [Google Scholar]

Articles from British Heart Journal are provided here courtesy of BMJ Publishing Group

RESOURCES